Fibrotouch与超声诊断脂肪肝一致性分析  

Consistency analysis of Fibrotouch and ultrasound examination in diagnosis of fatty liver

作　　者：温博[1] 王炳元[1] 李静波[1] 刘姝[1] 高楠[1] 王颖[2] 

机构地区：[1]中国医科大学附属第一医院老年消化科,沈阳110001 [2]中国医科大学附属第一医院消化内科,沈阳110001

出　　处：《中国肝脏病杂志（电子版）》2016年第2期19-23,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：中国肝炎防治基金会天晴肝病研究基金(20120101)

摘　　要：目的分析国产第三代影像引导肝脏瞬时弹性检测仪(Fibrotouch,FT)与超声诊断脂肪肝的一致性。方法选取2013年3月至2013年10月于中国医科大学附属第一医院干部体检中心进行体检的444例受试者。所有受试者接受问卷调查、体格测量、肝脏超声检查,Fibrotouch测定肝脏脂肪衰减参数及弹性值。所有数据采用SPSS 17.0统计软件包进行处理,运用单因素方差分析、Kappa检验、Spearson相关分析等方法进行统计分析。结果本研究共纳入444例受试者,男女比例为1∶1.36,平均年龄(49.95±14.5)岁,脂肪衰减参数为(238.47±37.70)db/m。经超声诊断为脂肪肝的患者共169例,检出率为38.06%;经Fibrotouch诊断为脂肪肝的患者共184例,检出率为41.44%;两种方法均诊断为脂肪肝的患者共138例,均未检出者229例,仅超声检出者31例,仅Fibrotouch检出者46例,两种诊断方法的符合率为82.66%,Kappa系数为0.638。结论 Fibrotouch与超声检查对脂肪肝诊断的总体符合度较高且一致性较好,Fibrotouch可对脂肪肝进行客观无创定量诊断,具有较好的临床应用前景。Objective To analyze the consistency between Fibrotouch and ultrasound examination in the diagnosis of fatty liver. Methods Patients were recruited in the First Affiliated Hospital of China Medical University from March 2013 to October 2013. All the participants received survey questionnaires, physical examinations and were measured by Fibrotouch and color Doppler ultrasound respectively. Data were analyzed by SPSS Statistics V17.0 software and expressed as mean ± standard deviation. Single-factor（one-way） analysis of variance（ANOVA）, Spearman rank correlation analysis, Kappa consistency test and Fisher＇s Least Significant Difference（LSD） were used. Results Total of 444 patients were recruited, the male-to-female ratio was 1∶1.36, the average age was（49.95 ± 14.5） years and the fat attenuation parameter（FAP） was（238.47 ± 37.70） db/m. Total of 169 and 184 cases were diagnosed as fatty liver by Fibrotouch and color Doppler ultrasound respectively, the detection rates were 38.06% and 41.44%. There were 138 cases who were diagnosed as fatty liver and 229 cases who were diagnosed with no fatty liver disease by both methods. Total of 31 and 46 cases were diagnosed as fatty liver only by color Doppler ultrasound or Fibrotouch only, respectively. The coincidence rate of the two methods was 82.66% and the Kappa value was 0.638. Conclusions There was a high conformity and consistency between Fibrotouch and color Doppler ultrasound examination in the diagnosis of fatty liver. As a non-invasive diagnostic technique, Fibrotouch is more accurate and valuable than color Doppler ultrasound, it can be effectively applied in the diagnosis of fatty liver in most cases.

关 键 词：脂肪肝 无创诊断 瞬时弹性成像 脂肪衰减度 Fibrotouch 

分 类 号：R575.5[医药卫生—消化系统]