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作 者:Rui Dong Xiao-Ou Zhang Yang Zhang Xu-Kai Ma Ling-Ling Chen Li Yang
机构地区:[1]Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2]State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [3]School of Life Science, ShanghaiTech University, Shanghai 200031, China
出 处:《Cell Research》2016年第6期747-750,共4页细胞研究(英文版)
基 金:Acknowledgments We are grateful to Gordon Carmichael for reading the manuscript. Next generation deep sequencing was performed at the CAS-MPG Partner Institute for Computational Biology Omits Core, Shanghai, China. This work is supported by grants 2014CB964800 and 2014CB910600 from the Ministry of Science and Technology of China, and grants 91540115, 91440202 and 31471241 from the National Natural Science Foundation of China.
摘 要:Circular RNAs (circRNAs) from pre-mRNA back-splicing have been recently re-discovered ge- nome-wide in metazoans by taking advantage of RNA deep-sequencing (RNA-seq) of the non-polyadenylated transcriptomes and specific computational pipelines that can retrieve the non-colinear back-splicing junction reads [1-5].
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