肾癌KI67基因扩增分析及其临床意义  

KI67 gene amplification in 47 patients with renal cancer and its clinical significance

作　　者：周凤娟[1] 黄倩[2] 郭雯雯[2] 辛勇[2] 

机构地区：[1]徐州医学院第二附属医院放疗科,江苏徐州221000 [2]徐州医学院附属医院放疗科

出　　处：《中国校医》2016年第7期507-509,共3页Chinese Journal of School Doctor

摘　　要：目的分析肾癌患者KI67基因扩增情况及其临床意义。方法收集47例肾癌患者的石蜡包埋组织样本,应用实时定量PCR法检测KI67基因扩增情况,收集患者的临床病理资料进行统计分析。结果 KI67基因在47例样本中的扩增率为48.9%(23/47)。KI67基因扩增患者中肿瘤浸润厚度>4 mm比例为72.7%(8/11),明显高于无扩增患者的27.3%(3/12),差异有统计学意义(Fisher精确概率法,P=0.039)。结论肾癌患者KI67基因扩增率较高,且预示患者存在不良预后因素。Objective To investigate the frequency of KI67 gene amplification in Chinese patients with renal cancer and explore its clinical significance. Methods We investigated KI67 gene amplification in tumor tissues obtained from 47 patients with renal cancer using quantitative real-time PCR. The clinical pathologicalmaterials were collected for further analysis. Results KI67 gene amplification was detected in 23 of 47 patients（48.9%）. The patients with KI67 amplification had a significantly higher rate of tumor thickness more than 4 mm（72.7%; Fisher＇s exact test, P=0.039）. Conclusion Our findings suggest that KI67 gene amplifications rate of Chinese renal cancer patients is higher, which seems the potential poor prognosis.

关 键 词：肾肿瘤 KI-67抗原 基因扩增 

分 类 号：R737[医药卫生—肿瘤]