Neuroprotective effect of angiotensin Ⅱ type 2 receptor during cerebral ischemia/reperfusion  

作　　者：Chun-ye Ma Lin Yin 

机构地区：[1]Department of Neurology, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China

出　　处：《Neural Regeneration Research》2016年第7期1102-1107,共6页中国神经再生研究（英文版）

摘　　要：Angiotensin Ⅱ type 2 receptor（AT2R） activation has been shown to protect against stroke,but its precise mechanism remains poorly understood.We investigated whether the protective effect of AT2 R against ischemia/reperfusion injury is mediated by the suppression of immune and inflammatory responses.Rat models of middle cerebral artery occlusion were intraperitoneally injected with physiological saline,the AT2 R agonist CGP42112（1 mg/kg per day） or antagonist PD123319（1 mg/kg per day）.In the CGP42112 group,AT2 R expression increased,the infarct area decreased,interleukin-1β and tumor necrosis factor-α expression decreased,and interleukin-10 expression increased compared with the saline group.Antagonisin AT2 R using PD123319 produced the opposite effects.These results indicate that AT2 R activation suppresses immune and inflammatory responses,and protects against cerebral ischemia/reperfusion injury.Angiotensin Ⅱ type 2 receptor（AT2R） activation has been shown to protect against stroke,but its precise mechanism remains poorly understood.We investigated whether the protective effect of AT2 R against ischemia/reperfusion injury is mediated by the suppression of immune and inflammatory responses.Rat models of middle cerebral artery occlusion were intraperitoneally injected with physiological saline,the AT2 R agonist CGP42112（1 mg/kg per day） or antagonist PD123319（1 mg/kg per day）.In the CGP42112 group,AT2 R expression increased,the infarct area decreased,interleukin-1β and tumor necrosis factor-α expression decreased,and interleukin-10 expression increased compared with the saline group.Antagonisin AT2 R using PD123319 produced the opposite effects.These results indicate that AT2 R activation suppresses immune and inflammatory responses,and protects against cerebral ischemia/reperfusion injury.

关 键 词：interleukin protective saline occlusion infarct understood suppression injected poorly physiological 

分 类 号：R743.3[医药卫生—神经病学与精神病学]