Mig-7、VEGF及血管生成拟态在口腔鳞癌中的表达及临床意义  

Expressions and clinical significance of Mig-7 and VEGF and vasculogenic mimicry in oral squamous cell carcinoma

作　　者：顾玉州 胡腾龙[1] 静广平[1] 于洋[1] 李席[1] 俞晴[1] 

机构地区：[1]哈尔滨医科大学附属口腔医学院口腔颌面外科,150001

出　　处：《现代口腔医学杂志》2016年第4期217-220,M0002,共5页Journal of Modern Stomatology

摘　　要：目的探讨口腔鳞癌(OSCC)组织中迁移诱导蛋白7(Mig-7)、血管内皮生长因子(VEGF)和血管生成拟态(VM)的表达及相关临床意义。方法选取80例OSCC患者石蜡标本,采用免疫组织化学染色方法检测其Mig-7、VEGF的表达情况,VM用CD34/PAS双重染色技术确定,并结合OSCC患者临床、病理及随访资料进行相关分析。结果在正常口腔黏膜组织中,VM、Mig-7及VEGF的表达率皆为0%,在80例OSCC组织中三者分别为41.25%、53.75%及71.25%,差异有统计学意义(P<0.05)。其中,VM及Mig-7的阳性表达与肿瘤的分化程度、颈部淋巴结转移情况及五年生存率有关(P<0.05),VEGF的阳性表达与肿瘤的颈部淋巴结转移情况及五年生存率有关(P<0.05),低分化组VM及Mig-7的阳性表达率明显高于中分化组及高分化组,有颈部淋巴结转移组VM、Mig-7及VEGF阳性率高于无颈部淋巴结转移组,VM、Mig-7及VEGF的表达与患者的五年生存率有关,阳性表达组的患者五年生存率明显低于阴性表达组。VM阳性组Mig-7及VEGF的阳性表达率明显高于VM阴性组。结论 OSCC组织中存在VM、Mig-7及VEGF的表达,Mig-7及VEGF的表达极有可能协同促进VM的形成,三者与OSCC的侵袭、转移及较差预后密切相关。Objective To investigate the expression and clinical significance of vasculogenic mimicry（VM）、migration-inducing protein 7（Mig-7） and vascular endothelial growth factor（VEGF） in oral squamous cell carcinomas（OSCC）. Methods Eighty surgical specimens of oral squamous cell carcinomas were examined for the expression of Mig-7 and VEGF using immunohistochemical staining.VM was determined by CD34/PAS double staining. Then we analyzed their correlations with the clinical and pathological charateristics of the patients. Results In normal oral mucosa, positive rates of 0%、0% and 0% were obtained for VM、Mig-7 and VEGF respectively. In OSCC,positive rates of41.25%、53.75% and 71.25% were obtained for VM、Mig-7 and VEGF respectively. VM and Mig-7 were correlated with grade of differentiation、cervical lymph nody metastasis and five year survival rate（P0.05）. VEGF was correlated with cervical lymph nody metastasis and five year survival rate（P0.05）. The positive expression rate of VM and Mig-7 in the poor differentiation group was significantly higher than that in the mediate and well differentiation group. The positive rate of VM, Mig-7 and VEGF in the group with cervical lymph node metastasis was higher than that in the group without cervical lymph node metastasis. The expression of VM, Mig-7 and VEGF was related to the five year survival rate of the patients,the five year survival rate of the patients with positive expression group was significantly lower than that of the negative expression group. The positive expression rate of Mig-7 and VEGF in VM positive group was significantly higher than that in VM negative group. Conclusion The expressions of VM、Mig-7 and VEGF in OSCC are proved. The high expressions of Mig-7 and VEGF in OSCC may have a synergistic promoting effect on VM formation. They are closely associated with the invasion, metastasis and poor prognosis of OSCC.

关 键 词：迁移诱导蛋白7 血管内皮生长因子 血管生成拟态 口腔鳞癌 预后 

分 类 号：R739.8[医药卫生—肿瘤]