柏薏灌肠液的提取工艺研究  

Optimization of Extraction Technology for Baiyi Rectal Solution

作　　者：李燕[1] 赵利刚 王慧丽[1] 郑丽娜[1] 阚淑月[1] 

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]华北理工大学药学院,河北唐山063000

出　　处：《中国药房》2016年第22期3145-3147,共3页China Pharmacy

摘　　要：目的:优化柏薏灌肠液的提取工艺。方法:采用星点设计-响应面法。以盐酸小檗碱、阿魏酸和干膏率的总评归一值(OD)为评价指标,考察加水量和提取时间对提取工艺的影响;同时进行验证试验。结果:最优提取工艺为第1次加11倍水煎煮70 min,第2次加5倍水煎煮30 min。验证试验中第1次提取的OD值为0.940 0,与预测值偏差-2.07%;第2次提取的OD值为0.851 8,与预测值偏差-2.41%。结论:柏薏灌肠液的提取工艺合理可行,适用于工业化生产。OBJECTIVE：To optimize the extraction technology of Baiyi rectal solution. METHODS：The effects of water amount and extraction time on extraction technology were investigated by central composite design-response surface method using OD value of berberine hydrochloride and ferulic acid and the extract yield as index. Validation test was also conducted. RESULTS：The optimal extraction technology was as 11-fold water,decocting 70 min for the first time;5-fold water,decocting 30 min for the second time. In validation test,OD value of first extraction was 0.940 0,and the bias between observed and predicted values was-2.07%;that of second extraction was 0.851 8,and the bias was-2.41%. CONCLUSIONS：The extraction technology of Baiyi rectal solution is reasonable,feasible and suitable for industrial production.

关 键 词：柏薏灌肠液 星点设计-响应面法 盐酸小檗碱 阿魏酸 干膏率 

分 类 号：TQ461[化学工程—制药化工]