ABCG1基因多态性与中国汉族人群缺血性脑卒中的相关性研究  

Association of ATP-binding Cassette Transporter G1 Polymorphism with Risk of Ischemic Stroke in Chinese Han Populations

作　　者：李瞿[1] 张小倩[1] 刘旭[1] 张慧媛[1] 姜懿凌[1] 何志义[1] 

机构地区：[1]中国医科大学附属第一医院神经内科,110001

出　　处：《中国临床神经科学》2016年第4期365-370,共6页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:81400950)

摘　　要：目的探讨ATP结合盒G亚组成员1(ABCG1)的基因多态性与缺血性脑卒中的相关性。方法采用病例-对照方法,在中国北方汉族人群中收集389例缺血性脑卒中患者(病例组)与380名正常体检者(对照组)进行对照研究。按改良的TOAST分型将病例组分为动脉粥样硬化血栓形成型亚组(207例)和小动脉闭塞型亚组(182例),采用聚合酶链式反应-连接酶检测方法测定ABCG1基因rs225374位点的多态性。结果在动脉粥样硬化血栓形成型亚组,rs225374位点GG基因型和G等位基因分布频率显著高于对照组(25.6%vs 17.9%,P=0.030;49.8%vs 43.4%,P=0.037);小动脉闭塞型亚组与对照组比较,rs225374位点的基因型和等位基因分布频率差异无显著性。结论 ABCG1基因rs225374位点的多态性与中国北方汉族人群动脉粥样硬化血栓形成性缺血性脑卒中的发病具有一定相关性。Aim To investigate the association between adenosine triphosphate（ATP）-binding cassette sub-family G member 1（ABCG1） polymorphism and the risk of developing ischemic stroke in a Chinese Han population. Methods This case–control study included 389 ischemic stroke patients and 380 healthy subjects. Ischemic stroke subtypes were classified according to Korean TOAST definitions. ABCG1 gene rs225374 was analyzed by a polymerase chain reaction-ligation detection reaction. ResultsSubtype analysis demonstrated that the frequency of rs225374 GG genotype and G allele was higher in the patient group with atherothrombotic stroke compared with that in the control group（25.6% vs17.9%, P=0.030; 49.8% vs 43.4%, P=0.037）. Logistic regression analysis revealed an increased risk of atherothrombotic stroke in a recessive model for rs225374. But there was no association found in the small artery disease subtype. Conclusion Data from the present study demonstrate that ABCG1 gene rs225374 polymorphism may be associated with the risk of developing atherothrombotic stroke in this cohort of Chinese Han population.

关 键 词：ATP结合盒G亚组成员1 ABCG1基因 基因多态性 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]