药物聚乙二醇化的研究进展  

Research Progress of PEGylation Used in Modifying Drugs

作　　者：刘凤英[1] 于英杰[1] 郑增娟[1] 

机构地区：[1]潍坊医学院药剂学教研室,潍坊261053

出　　处：《海峡药学》2016年第7期1-4,共4页Strait Pharmaceutical Journal

基　　金：山东省中医药科技发展计划项目(2013-241);山东省卫生和计划生育委员会科技计划项目(201410);国家科技部计划项目(2013GA740103)

摘　　要：聚乙二醇化是化学分子变构中重要的技术之一,是药物研究和开发的里程碑。本文介绍了聚乙二醇修饰药物的优化条件以及优化后药物在体内药动学和药效学等性质的改变,举例说明聚乙二醇化技术在蛋白多肽及纳米脂质体等方面的研究应用,并展望聚乙二醇修饰技术在国内外医药领域的应用前景。PEGylation is one of the important technologies in chemical molecule allosteric ,which is the milestone in drug research and development .In this study it was introduced the optimization conditions of PEG modified drugs that could improve the pharmacokinetic and pharmacodynamic properties in vivo ,and then reviewed the PEGylated pharmaceutical research and application such as protein ,polypeptide ,liposomes and nanoparticles .Finally PEGylation will be widely used in pharmaceutical field of domestic and foreign .

关 键 词：聚乙二醇化 蛋白质 多肽 脂质体 纳米粒 

分 类 号：R91[医药卫生—药学]