金纳米颗粒在肿瘤放射增敏中的研究进展  

Research advances in gold nanoparticle radiosensitization in radiotherapy for cancer

作　　者：聂芳芳[1] 张春富[2] 付杰[1] 

机构地区：[1]上海交通大学附属第六人民医院肿瘤放疗科,200233 [2]上海交通大学生物医学工程学院

出　　处：《中华放射肿瘤学杂志》2016年第8期907-910,共4页Chinese Journal of Radiation Oncology

基　　金：上海市科学技术委员会鼻咽癌自适应放射治疗临床研究项目（2011）

摘　　要：金纳米颗粒（ AuNPs）以其独特的理化性质及良好的生物相容性在生物医药方面广泛应用，其中金纳米颗粒肿瘤放射增敏作用是目前研究热点。大量体、内外研究证实AuNPs具有放射增敏效果，但AuNPs放射增敏相关机制仍有待进一步研究，目前普遍认为增敏主要由AuNPs促进肿瘤细胞由放疗不敏感期（ G0＋G1期）转为放疗敏感期（ G2＋M期）所致。影响AuNPs放射增敏效果的因素有很多，其中包括AuNPs粒径大小及其表面修饰和微观分布、放射线能量及剂量大小和肿瘤细胞类别等。此外值得注意的是，AuNPs用于肿瘤放射增敏的同时也要关注它的安全性。目前已开展了AuNPs有关临床试验，尚需继续进行AuNPs放射增敏的研究才能实现真正的临床转化。Gold nanoparticles （ AuNPs） have been widely used in biomedicine due to their unique physical and chemical properties as well as good biocompatibility. Current research in this field has been focused on AuNP radiosensitization in radiotherapy for cancer. Extensive studies in vivo and in vitro have showed the radiosensitization effect of AuNPs. However, the mechanism of radiosensitization by AuNPs still requires further studies. Right now, the radiation？insensitive phase （ G0＋G1 phase） to radiation？sensitive phase （ G2＋M phase ） transition of tumor cells by AuNPs is widely considered as the main cause of radiosensitization. There are many influencing factors for AuNP radiosensitization such as particle size, surface modification, microscopic distribution, radiation energy, radiation dose, and type of tumor cells. Moreover, safety should also be taken into account in AuNP radiosensitization. Clinical trials of AuNPs have been carried out right now. More studies on AuNP radiosensitization are needed to achieve real clinical transformation.

关 键 词：金纳米颗粒 放射增敏 肿瘤 细胞毒性 

分 类 号：R730.55[医药卫生—肿瘤]