《中国药典》收录的植物类中药中含有的寡肽类成分  

Oligopeptides in plant medicines cited in Chinese Pharmacopoeia

作　　者：苏磊 姜艳艳[1] 刘斌[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2016年第16期2943-2952,共10页China Journal of Chinese Materia Medica

基　　金：北京市教育委员会科技成果转化与产业化项目

摘　　要：2015年版《中国药典》中收录的茜草、亚麻子、紫菀、金铁锁、太子参、银柴胡、王不留行、瞿麦、青葙子、地骨皮、佛手、枳壳、人参、三七、北五味子、三棱、芡实、麦冬、半夏、牛膝、锦灯笼、玉竹和茺蔚子等23种中药中,已报道的寡肽类成分共187个。寡肽类成分主要为直链肽(二肽、三肽、五肽等)和环状肽(单环肽、双环肽、三环肽等),且以环状肽为主。单环肽有环二肽、环四-环十二肽等。双环肽主要从茜草和青葙子中分离得到。现代药理研究表明寡肽类成分具有抗肿瘤、抗菌、抗凝、免疫抑制等药理作用。In total, 23 plant plant medicined containing oligopeptides were cited in Chinese Pharmacopoeia （1 part） of 2015 version including Rubia cordifolia, Linum usitatissimum, Aster tataricus, Psammosilene tunicoides, Pseudostellaria heterophyUa, Stellaria dichoto- ma , Vaecaria segetalis , Dianthus superbus , Celosia argentea , Lycii Cortex, Citrus medica , C. aurantium , Panax ginseng, Parmx notog- inseng, Schisandra chinensis, Sparganium stoloniferum, Euryale ferox, Ophiopogon japonicas, Pinellia ternate, Achyranthes bidentata, Physalis alkekengi, Polygonatum odoratum, and Leonuri Fructus. There were 187 oligopeptides in plant medicinesabove as reported. O1- igopeptides consisted mainly of linear peptides and cyelie peptides. The linear peptides included dipeptides, tripeptides and pentapep- tides, and cyclic peptides included cyclic, bicyclie and tricyclic peptides. The number of residues of single cyclic peptides ranged from two to twelve. Bicyclic peptides were isolated mainly from R. cordifolia and C. argentea. Modem pharmacological study showed that oli- gopeptides had many pharmacological effects, including antitumor, anticoagulant, antibacterial, immune suppression and so on.

关 键 词：中国药典 中药 寡肽 环肽 结构 药理作用 

分 类 号：R284[医药卫生—中药学]