^(89)SrCl_2联合华蟾蜍素胶囊治疗恶性肿瘤骨转移的疗效及安全性研究  

Study on effect and safety of ^(89)SrCl_2 combined with Cinobufacini Capsule in treatment of multiple malignant tumor bone metastatic tumor by combination therapytasis

作　　者：李倩[1] 陈晓良[1] 

机构地区：[1]重庆市肿瘤医院/研究所/癌症中心核医学科,重庆400030

出　　处：《检验医学与临床》2016年第15期2082-2083,共2页Laboratory Medicine and Clinic

基　　金：重庆市卫生和计划生育委员会科技计划项目(ZY20150241)

摘　　要：目的比较^(89)SrCl_2和^(89)SrCl_2联合华蟾蜍素胶囊治疗恶性肿瘤骨转移的疗效及安全性研究。方法采取随机抽样的分组方法,分别应用^(89)SrCl_2及^(89)SrCl_2联合华蟾蜍素胶囊治疗恶性肿瘤骨转移瘤患者各30例,观察治疗后骨痛缓解和生活质量的情况,比较其骨转移病灶大小、数目的变化以及不良反应的发生情况。结果 ^(89)SrCl_2和^(89)SrCl_2联合华蟾蜍素胶囊止痛有效率分别为76.67%和83.33%,且差异有统计学意义(P<0.05);两组不良反应率比较,差异无统计学意义(P>0.05)。结论 ^(89)SrCl_2内照射治疗联合华蟾素胶囊能为恶性肿瘤骨转移患者提供更好的生存质量,并且不增加不良反应率的发生,是一种疗效较好的联合治疗方法。Objective To compare the clinical curative effects and safety between 89SrCl2 with 89SrCl2 combined with Cinobufaci‐ni Capsule in treating malignant tumor bone metastasis .Methods By adopting the random sampling and grouping method ,single 89 SrCl2 and 89 SrCl2 combined with Cinobufacini Capsule were used in treating 30 cases in each group .The ostalgia relieving and liv‐ing quality situation were observed .The size and number of bone metastasis lesions and adverse reactions were compared .Results The analgesic effective rates of single 89 SrCl2 and 89 SrCl2 combined with Cinobufacini Capsule were 76 .67% and 83 .33% respec‐tively ,and the difference was statistically significant（P〈0 .05）;the adverse reactions had no statistical difference between the two groups（P〉0 .05） .Conclusion The 89 SrCl2 internal irradiation therapy combined with Cinobufacini Capsule can provide better liv‐ing quality ,moreover without increasing the adverse reactions occurrence ,which is a combined treatment method with better effects .

关 键 词：多发性骨转移瘤 ^(89)SrCl_2 华蟾蜍素胶囊 

分 类 号：R738.1[医药卫生—肿瘤]