脂肪负荷餐对肝功能指标的影响  

Impact of fat load meal on liver function indices

作　　者：郑靖[1] 王佑娟[2] 刘雯[1] 舒世清[1] 王颖[1] 朱晓红[1] 苗佳[1] 

机构地区：[1]四川大学华西医院国家药物临床试验机构Ⅰ期病房,成都610041 [2]四川大学华西医院健康管理中心,成都610041

出　　处：《检验医学与临床》2016年第15期2084-2086,2089,共4页Laboratory Medicine and Clinic

基　　金：四川省科技厅项目(2011SZ0198;2010SZ0170)

摘　　要：目的评价脂肪负荷餐对血生化肝功能指标的影响,探索临床以非清晨空腹血进行肝功能检测的可行性。方法采用自身前后对照试验设计,603例受试者于空腹及进食脂肪负荷餐后2、4、6、8h采集血样,分别检测血生化肝功能指标,分析进餐前后肝功能指标的变化。结果进餐前、后不同时点肝功能指标的变化幅度非常小,且以餐后轻微降低多见。脂肪负荷餐对青年组与中年组、男性组与女性组、空腹血脂正常组与异常组餐后肝功能指标变化的影响,差异无统计学意义(P>0.05);对肝功能正常组和异常组餐后直接胆红素(DBiL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰基转移酶(γ-GT)的检测值变化过程的影响,差异有统计学意义(P<0.05)。但肝功能正常组和异常组餐后2、4、6h的检测值与空腹检测值之间的差异无统计学意义(P>0.05),故认为此差异无临床意义,不影响餐后肝功能指标的检测结果。结论脂肪负荷餐对肝功能指标检测无影响,肝功能检查可以随时抽血进行。Objective To evaluate the impact of the fat load meal on the liver function biochemical indices and to explore the fea‐sibility of using non‐fasting blood for conducting the liver function test .Methods Using the self controlled trial design ,the blood samples from 603 subjects at fasting and at 2 ,4 ,6 ,8 h after the fat load meal were collected to detect the liver function biochemical indices and the changes of liver function indices were compared between before and after meal .Results The changed amplitudes of liver function indices at different time points were very small ,moreover the majority were postprandial slight decreases .The impact of fat load meal on the changes of postprandial liver function indices had no statistical differences between the youth group and mid‐dle age group ,between the male group and female group ,between the fasting blood lipid normal group and abnormal group（P〉0 .05） .The impact of fat load meal on the changes of postprandial DBiL ,ALT ,AST and γ‐GT had statistical differences between the normal and the abnormal liver function groups（P〈0 .05） .But the detection values in the liver function normal group and abnor‐mal groups had no statistical differences between at fasting and at postprandial 2 ,4 ,6 h（P〉0 .05） ,therefore these changes could be considered as no clinical significance and had no impact on the detection results of postprandial liver function indices .Conclusion The fat load meal has no effect on the liver function indices testing ,the liver function test may be carried out at any time .

关 键 词：肝功能指标 脂肪负荷餐 餐前 餐后 

分 类 号：R851.8[医药卫生—航空、航天与航海医学]