不同证型抑郁症患者中西医结合治疗后抑郁情绪及认知功能改善分析  

Analysis of Depression and Cognitive Function in Patients with Different Syndrome Types of Depression Treated by Integrated Traditional Chinese and Western Medicine

作　　者：孙玉华[1] 李保平[1] 贺维亚[1] 赵静雅[1] 

机构地区：[1]河南大学淮河医院神经内科,河南开封475001

出　　处：《中华中医药学刊》2016年第8期1961-1963,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省教育厅自然科学研究项目(2007180008)

摘　　要：目的:分析不同证型抑郁症患者中西医结合治疗后抑郁情绪及认知功能改善情况。方法:选择2014年—2015年医院接诊的120例抑郁症患者进行研究,按照随机数表法将120例患者平均分为观察组和对照组两组,每组60例患者。对照组患者单纯给予西医常规抗抑郁剂-帕罗西汀片,观察组患者在对照组西医治疗的基础上,根据患者的中医证型进行中医治疗。两组患者治疗疗程均为8周,在患者治疗前、治疗后2周、治疗后4周、治疗后8周,分析两组患者临床治疗疗效,比较两组患者治疗前后HAMD、HAMA评分,观察并记录两组患者不良反应情况。结果:对照组患者临床治疗总有效率为73.33%,观察组患者临床治疗总有效率为90.00%,观察组明显高于对照组,两组患者临床治疗疗效差异具有统计学意义(P<0.05)。两组患者治疗前、治疗后2周HAMD评分差异不具统计学意义(P>0.05);两组患者治疗后4周、治疗后8周HAMD评分差异显著(P<0.05)。两组患者治疗前、治疗后2周HAMA差异不具统计学意义(P>0.05)。两组患者治疗后4周、治疗后8周HAMA差异明显(P<0.05)。两组患者治疗过程中出现不同程度的口干、恶心、排尿困难、食欲减退、便秘等不良反应。对照组患者总不良反应发生率为13.33%(8/60);观察组患者总不良反应率为6.67%(4/60)。两组患者不良反应情况差异不明显(P>0.05)。结论:根据抑郁症患者不同的中医证型进行中西医结合治疗后,患者的抑郁情绪及认知功能改善良好,临床治疗疗效显著提高,不良反应发生率下降,中西医结合的理念值得在临床推广应用。Objective： To analyze the improvement of depression and cognitive function in patients with different syndrome types of depression. Methods： One hundred and twenty patients with depression in our hospital in 2014 and 2015 were studied. According to the random number table method,the patients were divided into the observation group and the control group,60 in each group. The control group were only treated with routine antidepressants paroxetine tablets. Patients in the observation group were treated with Chinese medicine treatment according to TCM syndrome types. Treatment of the two groups lasted 8 weeks. Before treatment and 2,4 and 8 weeks after treatment,we analyzed the clinical treatment effect of the two groups and compared two groups’ scores of HAMD and HAMA and recorded the two groups’ adverse reactions. Results： The total effective rate of the control group was 73. 33% and of the observation group 90. 00% which was significantly higher than that of the control group. The difference of the two groups’ clinical curative effect was statistically significant（ P 〈 0. 05）. Before treatment and 2 weeks after treatment,HAMD scores in two groups were not statistically significant（ P 〉 0. 05）. Bur 4 and 8 weeks after treatment,the HAMD scores in two groups were significantly different（ P〈 0. 05）. Different degrees of dry mouth,nausea,difficulty in urination,appetite loss,constipation and other adverse reactions were appeared in the two groups during the treatment. The total adverse reaction rate was 13. 33%（ 8 /60） in control group and 6. 67%（ 4 /60） in the observation group. The adverse reactions of the two groups were not significantly different（ P 〉 0. 05）. Conclusion： According to depression patients with different syndromes of traditional Chinese medicine,the treatment of traditional Chinese and Western medicine significantly improves depression and cognitive function and lowers the adverse reaction occurrence. The combination of Chinese traditional and Western me

关 键 词：抑郁症 中西医 结合治疗 抑郁情绪 认知功能 改善 证型 

分 类 号：R749.4[医药卫生—神经病学与精神病学]