牙周基础治疗对2型糖尿病合并慢性牙周炎患者血清炎性指标及血糖代谢水平的影响  

Effects of periodontal basic therapy on blood glucose metabolism and serum biochemical indexes in patients with type2 diabetes mellitus complicated with chronic periodontitis

作　　者：任伟[1] 吴祥冰[1] 夏海霞[1] 於俊[1] 龚中坚[1] 

机构地区：[1]南京医科大学附属无锡人民医院口腔科,214023

出　　处：《疑难病杂志》2016年第8期817-820,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(青年科学基金项目)(81502347)

摘　　要：目的分析牙周基础治疗对2型糖尿病合并慢性牙周炎患者血清炎性指标及血糖代谢指标的影响。方法选取自2013年10月—2015年10月于南京医科大学附属无锡人民医院口腔科诊治的2型糖尿病合并慢性牙周炎患者64例作为研究对象,按照随机数字分配法将其平均分为2组,每组32例。其中对照组患者仅进行常规基线治疗,治疗组患者在常规基线治疗的基础上加用牙周基础治疗。治疗3个月后,观察比较2组患者血清炎性指标及血糖代谢指标的变化情况。结果(1)2组患者治疗后的龈沟出血指数、探诊深度较治疗前均有明显改善(观察组:t=2.384、15.189,P<0.05;对照组:t=13.448、7.096,P<0.05),且治疗后观察组较对照组改善更加明显(t=11.453、10.991,P<0.05);(2)2组患者治疗后的空腹血糖、糖化血红蛋白较治疗前均有明显改善(观察组:t=5.666、5.113,P<0.05;对照组:t=2.722、2.167,P<0.05),且治疗后观察组较对照组改善更加明显(t=3.874、2.363,P<0.05);(3)2组患者治疗后超敏C-反应蛋白、肿瘤坏死因子-α较治疗前均有明显改善(观察组:t=7.339、4.760,P<0.05;对照组:t=3.449、3.129,P均<0.05),且治疗后观察组较对照组改善更加明显(t=4.116、2.638,P均<0.05)。结论在2型糖尿病合并慢性牙周炎患者中应用牙周基础治疗可显著改善患者牙周环境,减轻牙周的炎性反应程度,并且对患者的血糖控制也有积极意义。Objective To observe and analyze the effect of periodontal basic treatment on blood glucose metabolism and serum inflammatory parameters in patients with type 2 diabetes mellitus complicated with chronic periodontitis.Methods Selected from October 2013 and October 2015, in our hospital, 64 cases of type 2 diabetes mellitus with chronic periodontitis patients were enrolled as the research object, according to the principle of random assignment, they were average into control group and observation group, 32 cases in each group.The control group patients only with routine baseline treatment, patients in the treatment group on the basis of conventional baseline treatment and with periodontal basic treatment.Three months after treatment, the indexes of blood glucose metabolism and serum biochemical indexes of changes were compared between the two groups of patients.Results （1） probing depth were significantly improved compared with before treatment of gingival sulcus after treatment in 2 groups, bleeding index （ observation group t =2.384,observation group t =15.189, P 〈0.05;control group t =13.448,control group t =7.096, P 〈0.05）, and after treatment in the observation group of patients with gingival sulcus bleeding index, probing depth is improved more than the control group obviously （ t =11.453, t =10.991, P 〈0.05）;（2） 2 groups of patients after treatment, fasting blood glucose and glycosylated hemoglobin were significantly im-proved compared with before treatment （observation group t =5.113,observation group t =5.666, P 〈0.05;control group t =2.722,control group t =2.167, P 〈0.05）,and after treatment, the patients in the observation group fasting blood glu-cose and glycosylated hemoglobin group improved more obviously than in the control（ t =3.874, t =2.363, P 〈0.05）;（3）the 2 groups of patients after treatment of high sensitivity C reactive protein,tumor necrosis factor alpha were significantly improved compared with before treatment （observation group：t =7.339, t =4.76

关 键 词：牙周基础治疗 糖尿病 2型 牙周炎 慢性 血清炎性指标 血糖代谢指标 

分 类 号：R781.4[医药卫生—口腔医学] R587.1[医药卫生—临床医学]