阿立哌唑缓解利培酮致女性精神分裂症患者泌乳素升高的临床研究  

作　　者：温娜[1] 唐伟[1] 潘建设[1] 章金良 

机构地区：[1]温州医科大学附属康宁医院,325000

出　　处：《浙江临床医学》2016年第9期1606-1608,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省温州市卫生局项目（2014833）

摘　　要：目的观察不同剂量的阿立哌唑对女性精神分裂症患者高泌乳素血症的缓解程度及疗效。方法因服用利培酮后引起高催乳素血症的女性精神分裂症患者200例，所有患者均维持原利培酮的治疗方案，根据随机数字表将患者分为阿立哌唑15mg／d50例（15mg组），10mg／d50例（10mg组），5mg／d50例（5mg组）和安慰剂组50例，四组患者干预4N后测量患者催乳素水平，同时采用不良反应量表（TESS）评定阿立哌唑治疗的不良反应。结果与安慰剂组比较，阿立哌唑治疗后泌乳素水平显著下降，差异有统计学意义（P〈0．01）。TESS评分15mg组（5．12±1．12）分，10mg组（5．18±1．06）分，5mg组（4．98±1．01）分，安慰剂组（4．98±1．08）分，四组间差异无统计学意义（P〉0.05）。结论阿立哌唑能有效改善并l】培酮所致体重、泌乳素增加症状，且安全、可靠，值得临床应用和推广。Objective To evaluate the dose effects of adjunctive treatment with aripiprazole on prolactin levels and hyperprolactinemia in schizophrenia patients. Methods 200 cases of hyperprolactinemia patients casued by risperidone were randomly assigned to receive 4 weeks of placebo （ n=50 ） or oral aripiprzole 15rag/day （ n=50 ） , 10 mg/day （ n=50 ） , 5mg/day （ n=50 ） added on to fixed dose risperidone treatment. Serum prolactin levels were measured at baseline and after 1, 2 and 4 weeks. Clinical symptoms and side effects were assessed at baseline and week 4. Results All three aripiprzole doses resulted in significantly lower prolactin levels （ P〈0.01 ） . No significant changes were observed in any treatment groups regarding adverse effect ratings. In the 15mg group, the TESS score was （ 5.12± 1.12 ） , the 10mg group was 5.18± 1.06, the 5mg group was 4.98 ± 1.01 and the placebo group was 4.98 ± 1.08. Conclusion Adjunctive aripiprazole treatment was effective and safe for resolving risperidone- induced hyperprolactinemia without significant effects on psychopathology and side effects. It is worthy of clinical application and promotion.

关 键 词：阿立哌唑 利培酮 高泌乳素血症 剂量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]