全脑放疗联合γ-刀局部加量治疗脑转移瘤的临床疗效  

Clinical effect of whole-brain radiotherapy combined with γ-knife in treatment of brain metastases

作　　者：张倩[1] 胡力宏 宋旭旭[1] 王顺[1] 杨杰智[1] 

机构地区：[1]解放军150医院肿瘤科,河南洛阳471000

出　　处：《医疗卫生装备》2016年第7期87-89,100,共4页Chinese Medical Equipment Journal

摘　　要：目的:探讨肺癌脑转移瘤使用单纯全脑放疗与联合γ-刀局部加量放疗的临床疗效差异。方法:选择60名肺癌脑转移患者,随机分为A、B 2组,每组30人,A组接受全脑照射治疗,B组接受全脑照射治疗后行γ-刀局部加量治疗。对比2组患者颅内肿瘤缩小程度、客观缓解率、总生存期。结果:A组患者颅内肿瘤缩小程度小于B组患者(P<0.05);A组患者客观缓解率小于B组患者(P<0.05);A组患者较B组患者总生存期短,且存在明显差异(P<0.05)。结论:全脑放疗可提高肺癌颅内转移患者总生存期,全脑放疗后对于颅内肿瘤进行局部γ-刀治疗可使颅内肿瘤明显缩小,且加量后患者总生存时间较非加量组长且存在明显统计学差异。Objective To compare the clinical effects on brain metastases of lung cancer by whole-brain radiotherapy or whole-brain radiotherapy combined with γ-knife. Methods Totally 60 brain metastases patients were divided randomly and equally into group A and group B. The ones in group A underwent whole-brain radiotherapy, and the ones in group B went through γ-knife treatment after whole-brain radiotherapy. The patients in the two groups were compared for the tumor reduction, objective response rate（ORR） and overall survival（OS）. Results The reduction of intracranial tumor in group A was less than that in group B（P 0.05）; The ORR of group A was less than that of group B（P 0.05）; The OS of group A was significantly shorter than that of group B（P0.05）. Conclusion The whole brain radiation therapy can improve the OS of the patients with brain metastasis from lung cancer. After whole-brain radiotherapy, augmented local dosage γ- knife treatment can significantly reduce the size of intracranial tumor, and the overall survival time is significantly longer than that of non additive group.

关 键 词：脑转移瘤 全脑放疗 γ-刀局部加量 临床疗效 

分 类 号：R739.41[医药卫生—肿瘤] R730.55[医药卫生—临床医学]