老年脑卒中后卧床患者下肢深静脉血栓发生的影响因素调查  

Risk factors of deep venous thrombosis of lower extremity in elderly patients after stroke

作　　者：鲁敏晔[1] 

机构地区：[1]浙江省人民医院神经内科,浙江杭州310024

出　　处：《中华全科医学》2016年第10期1710-1712,共3页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2010KYB007)

摘　　要：目的探讨老年脑卒中后卧床患者下肢深静脉血栓发生影响因素,为实施预防性干预措施提供参考。方法采用回顾性分析方法对2014年1月—2015年7月在浙江省人民医院诊治的448例老年脑卒中后卧床患者的临床资料进行分析,采用单因素分析和多因素logistic回归分析影响下肢深静脉血栓发生的高危因素。结果448例老年脑卒中后卧床患者中有25例发生下肢深静脉血栓,发生率为5.58%;单因素分析显示:脱水剂使用、静脉炎、合并高血压、合并糖尿病、高脂血症、感染、肿瘤、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、CD62p、CD63、纤溶酶原激活抑制物-1(PAI-1)、血小板聚集等是老年患者脑卒中后深静脉血栓发生的危险因素(P<0.05);Logistic回归分析显示,脱水剂使用、静脉炎、合并高血压、感染、肿瘤、hs-CRP升高、D-D升高、CD62p升高、CD63升高、PAI-1升高、血小板聚集升高等是老年患者脑卒中后下肢深静脉血栓发生的独立因素(P<0.05)。结论脱水剂使用、静脉炎、合并高血压、感染、肿瘤、hs-CRP升高、D-D升高、CD62p升高、CD63升高、PAI-1升高、血小板聚集升高等是脑卒中后卧床患者下肢深静脉血栓发生的影响因素,应采取针对性的干预措施,以减少深静脉血栓发生率。Objective To explore the risk factors of the deep venous thrombosis of lower extremity in elderly patients after stroke,and to provide reference for the preventive interventions. Methods From January,2014 to July,2015 ,the clinical data of 448 elderly bedridden patients after stroke were analyzed retrospectively. The risk factors were analyzed by single factor analysis and multi factor Logistic regression analysis. Results There were 25 cases of deep venous thrombosis of lower extremity among 448 patients after stroke with a rate of 5.58% ; Single factor analysis showed that dehydrating agent, phlebitis, hypertension, diabetes, hyperlipidemia, infection, tumor, and the elevated levels of hs-CRP, D-dimer, CD62p, CD63 PAI-1 and platelet aggregation were the risk factors of deep vein thrombosis （ P 〈 0.05 ） ; Logistic regression analysis showed that dehydrating agent, phlebitis, hypertension, infection, tumor, and the elevated levels of hs-CRP, D-dimer, CD62p CD63, PAI-1 and platelet aggregation were the independent risk factors for the deep venous thrombosis in the elderly patients after stroke （ P 〈 0.05 ）. Conclusion Dehydrating agent, phlebitis, hypertension,infection, tumor, and the elevated levels of hs-CRP, D-dimer, CD62p CD63, PAI-1 and platelet aggregation are the independent risk factors for the deep venous thrombosis of lower limb in the elderly patients after stroke, and the intervention measures should be taken to reduce the incidence of deep venous thrombosis.

关 键 词：脑卒中 卧床患者 下肢深静脉血栓发生 影响因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R654.4[医药卫生—临床医学]