AML1-ETO阳性的儿童急性髓系白血病的诊治分析  

Study of AMLl-ETO positive childhood acute myeloid leukemia

作　　者：赖长城[1] 李艳红[1] 梁昌达[1] 何飞[1] 

机构地区：[1]江西省儿童医院血液科,南昌330006

出　　处：《江西医药》2016年第7期615-618,共4页Jiangxi Medical Journal

摘　　要：目的探讨AML1-ETO阳性的儿童急性髓系白血病的临床及生物学特征,比较不同剂量阿糖胞苷缓解后治疗与预后的关系。方法分析AML-ETO阳性的儿童急性髓系白血病患者的临床特征,包括细胞形态学、血象、染色体核型、治疗效果及预后。诱导缓解治疗采用DAE/HAE/IA方案,缓解后进行6-10个疗程的联合化疗,根据缓解后化疗所用阿糖胞苷的剂量不同分为A、B两组。结果 43例AML1-ETO阳性的儿童急性髓系白血病初治患儿中,男24例,女19例,中位年龄9(2-15)岁;1疗程完全缓解率77.1%,2疗程完全缓解率94.3%。A,B两组间无事故生存期比较无统计学意义。结论儿童AML-ETO急性髓系白血病中,男性居多,年长儿多发。有无附加染色体对预后无明显影响,应用中大剂量阿糖胞苷联合化疗远期疗效好。Objective To evaluate the clinical and biological characteristics of children acute myeloid leukemia with AML1-ETO,and to compare the relationship between treatment and prognosis of the patients with different doses of cytosine arabinoside.Methods To study the clinical features of children acute myeloid leukemia patients with AML1-ETO,including cell morphology,hematologic,karyotype,treatment effect and prognosis. The induction chemotherapy included DAE,HAE,IA. The patients received 6-10 cycles intensive postremission chemotherapy after achieving remission. They were divided into A、B two groups According to doses of cytosine arabinoside. Results 43 cases of children acute myeloid leukemia were diagnosed as AML1-ETO positive,24 male,19 female,median age of 9（2-15） years old,one course of complete remission rate of 77.1%,two course of complete remission rate of 94.3%. A、B two group event-free survival was not statistically significant. Conclusion Boy and adolescent was preferential In children acute myeloid leukemia with AML-ETO. There was no significant effect on the prognosis of the patients with additional chromosomal and there was a good long-term prognosis with large doses of cytosine arabinoside combination chemotherapy.

关 键 词：白血病 髓系 儿童 AML1-ETO 

分 类 号：R733.71[医药卫生—肿瘤]