动脉介入新辅助化疗对局部晚期宫颈癌患者的疗效观察  

Observation of interventional neoadjuvant chemotherapy in patients with locally advanced cervical cancer effect of artery

作　　者：孙雪松[1] 闫亚娟[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇瘤科,北京100006

出　　处：《中国医刊》2016年第8期65-67,共3页Chinese Journal of Medicine

摘　　要：目的分析动脉介入新辅助化疗对局部晚期宫颈癌患者的治疗效果。方法选取2013年3月至2015年2月于本院就诊的130例宫颈癌患者,根据患者病情、家属意愿及经济状况分为研究组(n=62例)和对照组(n=68例),分别采用动脉介入新辅助化疗联合手术治疗和直接手术治疗,化疗方案为紫杉醇联合顺铂。观察研究组患者经治疗后的疗效及不良反应程度,比较两组术中出血和术后病理特征,以评价新辅助化疗的疗效。结果两组患者在年龄、肿瘤分期、组织病理类型、肿瘤细胞分化程度方面差异无显著性(P>0.05)。研究组患者的局部病灶完全缓解率为14.5%,部分缓解率为85.5%;化疗期间未出现严重不良反应;研究组术中出血量较对照组减少,但差异无显著性(P>0.05)。研究组患者浸润肌层≥1/2占50.0%,对照组占78.0%;研究组患者的脉管癌栓发生率为11.3%,对照组为70.6%;研究组患者的淋巴结转移发生率为4.8%,对照组为19.1%;两组比较差异有显著性(P<0.05)。结论动脉介入新辅助化疗治疗局部晚期宫颈癌患者安全、有效。Objective Study on curative effect of interventional neoadjuvant chemotherapy for locally advanced cervical cancer. Method The clinical data of 130 cases of cervical cancer were collected. The study group was 62 cases, and the TP was the new adjuvant chemotherapy combined with interventional chemotherapy. The control group was 68 cases. To observe the efficacy and toxicity of neoadjuvant chemotherapy in the treatment of cervical lesions in the study group, and to evaluate the efficacy of neoadjuvant chemotherapy in the treatment of two groups of bleeding and postoperative pathologic features. Result There was no significant difference between the study group and the control group in terms of age, FIGO stage, pathological type, cell differentiation degree and so on. The complete remission rate of the patients in the study group was 14.5%, the partial remission rate was 85.5%, and there was no serious side effect of chemotherapy during chemotherapy. The amount of bleeding in the study group was significantly lower than that in the control group. Research group of invading the muscle layer is more than or equal to 1/2 rate was 50.0%, control group was 78%;the study group of cancer embolus rate was 11.3%, control group was 70.6%; group of lymph node metastasis rate was 4.8% and control group was 19.1%. The difference between the two groups have significant（P〈0.05）. Conclusion Safety and effective treatment for locally advanced cervical cancer with neoadjuvant chemotherapy.

关 键 词：宫颈肿瘤 新辅助化疗 动脉介入化疗 疗效 

分 类 号：R737.33[医药卫生—肿瘤]