应激及肠道屏障功能障碍在炎症性肠病中的作用  

Role of stress and intestinal barrier dysfunction in inflammatory bowel disease

作　　者：王树玲[1] 赵胜兵[1] 方军[1] 马丹[1] 符宏宇[1] 李兆申[1] 柏愚[1] 

机构地区：[1]上海第二军医大学长海医院消化内科,上海市200433

出　　处：《世界华人消化杂志》2016年第21期3248-3254,共7页World Chinese Journal of Digestology

基　　金：第二军医大学优秀青年学者基金资助项目;No.201301;2014年上海市青年科技启明星计划(A类)基金资助项目;No.14QA14044800~~

摘　　要：应激是机体在各种内外环境因素刺激时所出现的生理及心理等全身性非特异性适应反应.肠道是人体重要的消化吸收器官,同时通过肠黏膜将肠腔与机体内环境相隔,防止肠腔内的细菌、内毒素等有毒物质进入体内,发挥重要的屏障功能,研究表明肠道是应激状态下最易受损的器官.目前,炎症性肠病的病因和发病机制尚不明确,研究证实除基因易感性外,环境因素与其发病率的急剧上升密切相关.众多研究发现应激与炎症性肠病的发生、发展、治疗、复发及预后密切相关,因此对两者之间关系及发病机制的研究具有十分重要的临床意义.Stress,provoked by stressors,can cause a series of physical and psychological reactions and initiate both central and peripheral responses to maintain homeostasis.The causes of inflammatory bowel disease are poorly understood,which may involve complex interactions among environmental,psychological,dietary,immunological and pharmacological factors.This paper reviews the epidemiological and clinical data on how stress may precipitate in the attack,relapse and recurrence of inflammatory bowel disease.A possible biological mechanism is the impaired intestinal barrier including physical barrier,biologic barrier,immunological barrier and chemical barrier.Clinical epidemiological data and many animal studies show that stress may reduce mucous secretion and increase colonic permeability,which are the characteristic changes of inflammatory bowel disease.Understanding the relationship between stress and inflammatory bowel disease can improve the health related quality of life and lower the medical cost.

关 键 词：应激 肠道黏膜屏障障碍 炎症性肠病 机制 

分 类 号：R574[医药卫生—消化系统]