抗血小板聚集药物致上消化道出血的影响因素研究  

Research of influence factors by anti-platelet aggregation drug inducing upper gastrointestinal hemorrhage

作　　者：牛浩 

机构地区：[1]东莞市中堂医院,523221

出　　处：《中国实用医药》2016年第20期10-11,共2页China Practical Medicine

摘　　要：目的分析抗血小板聚集药物致上消化道出血的影响因素。方法 182例接受经皮冠状动脉介入治疗(PCI)、并服用双联抗血小板聚集药物的冠心病患者,收集其一般资料和临床资料,对比不同因素的消化道出血情况,分析抗血小板聚集药物致上消化道出血的影响因素。结果 182例患者中共18例患者发生上消化道出血,发生率为9.9%。单因素分析结果显示抗血小板聚集药物致患者上消化道出血的影响因素包括性别、年龄、疾病史、血小板计数异常、吸烟史、抗血小板药物使用时间、肌酐表达水平、血红蛋白量(P<0.05),多因素分析结果显示年龄、血红蛋白量、肌酐表达水平、吸烟史、血小板计数为独立影响因素(P<0.05)。结论抗血小板聚集药物致患者上消化道出血的影响因素较多,临床应积极分析,及时采取措施预防,以降低患者的上消化道出血发生率。Objective To analyze influence factors by anti-platelet aggregation drug inducing upper gastrointestinal hemorrhage. Methods General and clinical data were collected from 182 coronary heart disease patients, who received percutaneous coronary intervention（PCI） and dual anti-platelet aggregation drug. Comparison was made on gastrointestinal hemorrhage with different factors to analyze influence factors by antiplatelet aggregation drug inducing upper gastrointestinal hemorrhage. Results Among the 182 patients, there were 18 cases with upper gastrointestinal hemorrhage, with incidence as 9.9%. Univariate analysis showed influence factors for anti-platelet aggregation drug-induced upper gastrointestinal hemorrhage as gender, age, medical history, abnormal platelet count, smoking history, anti-platelet aggregation drug administration time, creatinine expression level, and hemoglobin level（P〈0.05）. Multivariate analysis showed age, hemoglobin level, creatinine expression level, smoking history and platelet count as independent influence factors（P〈0.05）. Conclusion There are multiple influence factors for anti-platelet aggregation drug-induced upper gastrointestinal hemorrhage. Active clinical analysis and timely measure implement are necessary to reduce incidence of upper gastrointestinal hemorrhage.

关 键 词：上消化道出血 抗血小板聚集 影响 研究 

分 类 号：R573.2[医药卫生—消化系统]