生发中心与非生发中心型弥漫大B细胞淋巴瘤的临床病理因素分析  

Analysis of clinical pathological factors of germinal center type and non-germinal center type diffuse large B-cell lymphoma

作　　者：柴晓菲[1] 宋魏[1] 孙淼淼[1] 张建波[1] 于庆凯[1] 宋永平[1] 

机构地区：[1]河南省肿瘤医院郑州大学附属肿瘤医院病理科,450008

出　　处：《中国实用医药》2016年第20期20-21,共2页China Practical Medicine

摘　　要：目的探讨生发中心型(GCB)与非生发中心型(non-GCB)弥漫大B细胞淋巴瘤临床病理因素及其与预后关系。方法 98例经组织学和免疫组化确诊的弥漫大B细胞淋巴瘤患者,按照Hans免疫分型,GCB型21例(A组),non-GCB型77例(B组),比较两组生存率,分析影响预后的相关因素。结果 A组生存率高于B组(P<0.05);多因素分析显示,两组乳酸脱氢酶(LDH)水平、国际预后指数(IPI)比较差异有统计学意义(P<0.05),LDH、IPI为弥漫大B细胞淋巴瘤的独立预后因素。结论在弥漫大B细胞淋巴瘤中,non-GCB型更为常见,LDH、IPI评分是影响non-GCB型预后的主要因素,应根据患者实际情况选择合适的治疗方案。Objective To investigate relationship between clinical pathological factors and prognosis in germinal center type （GCB） and non-germinal center type （non-GCB） diffuse large B-cell lymphoma. Methods A total of 98 patients with histologically and immunohistochemically diagnosed diffuse large B-cell lymphoma were divided by Hans immunophenotyping into 21 GCB cases （group A） and 77 non-GCB cases （group B）. Survival rate was compared between the two groups, and influencing factors of prognosis were analyzed. Results Group A had higher survival rate than group B （P〈0.05）. The difference of lactate dehydrogenase （LDH） level and international prognostic index （IPI） shown by multivariate analysis had statistical significance between the two groups （P〈0.05）. LDH and IPI were the independent prognosis factors for diffuse large B-cell lymphoma. Conclusion Among diffuse large B-cell lymphoma cases, non-GCB ones are common. LDH and IPI scores are main influencing factors for non-GCB prognosis. Treatment measures should be made in accordance with actual condition of patients.

关 键 词：弥漫大B细胞淋巴瘤 乳酸脱氢酶 国际预后指数 

分 类 号：R733.1[医药卫生—肿瘤]