乳腺癌转移抑制基因1表达与肿瘤发生发展相关性的Meta分析  

Breast cancer metastasis suppressor gene 1 correlates with progression of cancer： a Meta-analysis

作　　者：潘中亚 龙行华[1] 

机构地区：[1]武汉大学中南医院检验科,430071

出　　处：《国际肿瘤学杂志》2016年第8期603-608,共6页Journal of International Oncology

基　　金：国家自然科学基金（30873044、81272372）;教育部留学回国人员科研启动基金（[2011]1139）

摘　　要：目的 探讨乳腺癌转移抑制基因1（BRMS1）的表达与肿瘤发生发展的相关性，为预测肿瘤的发生和转移提供依据。方法 从PubMed、EMBase、中国期刊全文数据库（CNKI）、万方医药期刊全文数据库、维普中文科技期刊全文数据库等检索BRMS1与肿瘤发生的临床研究文献，用比值比（OR）评价肿瘤发生与BRMS1阳性表达率的关系。原始数据汇总后用RevMan 5.3软件进行统计分析。结果 共纳入文献27篇，其中肿瘤病例组2 282例，非肿瘤对照组1 236例，合并OR值为0.10，95％CI为0.08-0.14，BRMS1在两组中的表达差异有统计学意义（Z=15.37，P＜0.000 01）。在有关肿瘤类型亚组中，乳腺癌合并OR值为0.10，95％CI为0.05-0.20，BRMS1在乳腺癌和非乳腺癌组织中的表达差异有统计学意义（Z=6.18，P＜0.000 01）。结论 BRMS1的阳性表达与肿瘤的发生呈负相关，同时BRMS1的阳性表达与乳腺癌的发生也呈负相关。BRMS1在肿瘤组织中低表达或者缺失，其有望作为预测肿瘤发生和转移的生物标志物。Objective To evaluate the association between the expression of breast cancer metastasis suppressor gene 1 （BRMS1） and the progression of cancer, and provide the basis for predicting the occurrence and metastasis of cancer. Methods Articles about BRMS1 with the clinical research literatures of cancer from PubMed, EMBase, China National Knowledge Infrastructure, Wanfang and VIP database were retrieved. The association between the expression of BRMS1 and tumorigenesis was evaluated by odds ratio （OR）. The RevMan 5.3 software was used to complete the meta-analysis. Results A total of 27 articles were included, involving 2 282 cases in cancer group and 1 236 cases in the control group. The metaanalysis results showed that BRMS1 expression was significantly upregulated in cancer lesions compared with paired noncancer （OR= 0.10, 95%CI： 0.080.14, Z=15.37, P〈0.000 01）. In the subgroup about the type of cancers, there was statistically significant difference in the pooled OR between breast cancer and the control group （OR=0.10, 95%CI： 0.050.20, Z=6.18, P〈0.000 01）. Conclusion The level of BRMS1 is negatively correlated with tumorigenesis including breast cancer. Low or absent BRMS1 expression in the tumor tissue may be an adverse predictive factor of tumorigenesis and metastasis.

关 键 词：肿瘤 META分析 乳腺癌转移抑制基因1 

分 类 号：R730.231[医药卫生—肿瘤]