CCR7和VEGF-C蛋白与乳腺癌预后之间的关系  

Expression of chemokine receptor CCR7 and VEGF-C is associated with prognosis of breast carcinoma

作　　者：刘清华[1] 于国华[2] 刘雨清[3] 

机构地区：[1]潍坊医学院人体解剖学教研室,山东潍坊261053 [2]潍坊医学院病理学教研室,山东潍坊261053 [3]潍坊市人民医院肿瘤内科,山东潍坊261041

出　　处：《中国病理生理杂志》2016年第8期1457-1460,1465,共5页Chinese Journal of Pathophysiology

基　　金：山东省自然科学基金资助项目(No.ZR2014HL077)

摘　　要：目的:探讨趋化因子受体7(CCR7)及血管内皮生长因子C(VEGF-C)蛋白在乳腺癌组织中的表达水平,并分析二者与乳腺癌预后的关系。方法:采用免疫组织化学技术,联合检测CCR7和VEGF-C蛋白分别在乳腺癌组织及正常乳腺组织中的表达差异情况,并分析二者与乳腺癌各相关临床病理特征之间的关系。采用Kaplan-Meier法来评估CCR7及VEGF-C蛋白的异常表达与乳腺癌患者生存期之间的关系。结果:CCR7蛋白在乳腺癌组织(68%)中的阳性表达率高于正常乳腺组织(30%),差异有统计学显著性(P<0.01);而VEGF-C蛋白在乳腺癌组织(71%)中的阳性表达率也明显高于正常乳腺组织(24%),差异也有统计学显著性(P<0.01)。且在乳腺癌组织中,CCR7与VEGF-C蛋白的表达呈正相关关系(r=0.613,P<0.01)。CCR7和VEGF-C蛋白的高表达均与淋巴结转移和TNM分期有关(P<0.05),而与年龄、肿瘤大小、雌激素受体和孕激素受体均无关。CCR7及VEGFC蛋白阳性表达者的生存期低于阴性表达者,两组比较差异有统计学显著性(P<0.05)。结论:CCR7与VEGF-C的异常高表达可能与乳腺癌预后关系密切,二者可作为判断乳腺癌预后不良的重要指标之一。AIM： To explore the protein levels of chemokine receptor 7（CCR7） and vascular endothelial growth factor（ VEGF）-C in breast carcinoma,and to investigate the effects of CCR7 and VEGF-C on prognosis of breast carcinoma. METHODS： The protein expression levels of CCR7 and VEGF-C in the breast carcinoma tissues and normal breast tissues were detected by the method of immunohistochemistry. At the same time,the relationship between clinicopathologic characteristics and the protein expression of CCR7 and VEGF-C in the breast carcinoma tissues was analyzed.The relationship between the protein expression of CCR7 and VEGF-C and survival time of the breast cancer patients was estimated by Kaplan-Meier method. RESULTS： The positive expression rates of CCR7 and VEGF-C in the breast carcinoma tissues were significantly higher than those in the normal breast tissues（ P 0. 01）. A positive correlation was observed between the protein expression of CCR7 and the protein expression of VEGF-C in the breast carcinoma tissues（ r = 0. 613,P 0. 01）. The protein expression of CCR7 and VEGF-C was correlated with lymph node metastasis and TNM stage（ P 0. 05）,but both were not related to patients＇ age,primary tumor size,estrogen receptor and progesterone receptor. The survival time of the patients with CCR7 and VEGF-C positive expression was significantly shorter than that of the patients without the expression（ P 0. 05）. CONCLUSION： The positive expression of CCR7 and VEGF-C proteins is associated with the prognosis of breast cancer,and combined detection of CCR7 and VEGF-C protein expression levels may be helpful to judge the prognosis of breast cancer.

关 键 词：趋化因子受体7 血管内皮生长因子C 乳腺癌 

分 类 号：R730.23[医药卫生—肿瘤]