晚期糖基化终末产物受体在人子宫内膜癌中的表达及意义  

The expression of receptor for advanced glycation endproducts in endometrial carcinoma

作　　者：郑璐[1] 孟斐[1] 李彤[1] 刘伟[1] 

机构地区：[1]沈阳医学院附属中心医院妇产科,辽宁沈阳110024

出　　处：《现代肿瘤医学》2016年第17期2670-2673,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81272874);辽宁省自然科学基金(编号:2014010136-301);沈阳医学院科技基金(编号:20131021)

摘　　要：目的:探讨晚期糖基化终末产物受体(RAGE)的表达是否与子宫内膜癌相关,并进一步分析其可能机制。方法:收集手术切除的子宫内膜癌石蜡标本,免疫组化方法检测内膜癌组织中RAGE的表达及微血管密度,利用图像分析系统分析RAGE蛋白在子宫内膜癌组织中的表达情况,以平均光密度值(IOD)代表RAGE的表达水平。用Pearson相关性分析来分析子宫内膜癌组织中RAGE与微血管密度的相关性。结果:与正常子宫内膜组织相比RAGE在内膜癌组织中呈显著高表达(P<0.01),且在高度恶性的癌组织中的表达显著高于低度恶性癌组织(P<0.05)。子宫内膜癌患者癌组织中RAGE表达量与微血管密度呈正相关。结论:RAGE在子宫内膜癌中高表达,与内膜癌发生发展及血管新生相关。Objective：To explore whether the receptor for advanced glycation endproducts（ RAGE） is associated with the occurrence of endometrial carcinoma and further analyze the possible mechanism.Methods：The endometrial carcinoma specimens were collected.The RAGE expression and microvessel density in endometrial carcinoma tissues were detected by immunohistochemistry,and their relation was analyzed.RAGE protein expression levels in the non-cancerized endometrium and endometrial carcinoma tissues were analyzed with the image analysis system and presented RAGE expression level with IOD.Results：Compared with normal endometrial tissues group,the significantly high expression of RAGE was found in endometrial carcinoma tissues（ P〈0.01）,and RAGE expression level in the high-grade malignant cancer tissues was markedly greater than that in the low-grade malignant cancer tissues（ P〈0.05）.The expression level of RAGE in endometrial carcinoma tissues was positively correlated with microvessel density.Conclusion：RAGE is highly expressed in endometrial carcinoma patients and associated with the occurrence and angiogenesis of endometrial carcinoma.

关 键 词：子宫内膜癌 晚期糖基化终末产物受体 微血管密度 血管新生 

分 类 号：R737.33[医药卫生—肿瘤]