黄腐酚抑制人前列腺癌PC3细胞增殖机制初探  

Mechanism of Xanthohumol inhibits human prostate cancer PC3 cell proliferation

作　　者：张文超[1] 周程[1] 刘峰[1,2] 孙枝红 马涟清 刘启明 杜宇平[1] 王勤[1] 

机构地区：[1]兰州大学生命科学学院,甘肃兰州730000 [2]石药集团中央药物研究院,河北石家庄050000 [3]甘肃盛康医药科技有限公司,甘肃兰州730000 [4]玉门拓璞科技开发有限责任公司,甘肃玉门735211

出　　处：《现代肿瘤医学》2016年第17期2681-2685,共5页Journal of Modern Oncology

基　　金：兰州大学科研合作(校企横向合作)项目[编号:0718(11)]

摘　　要：目的:初步探讨黄腐酚抑制人前列腺癌PC3细胞增殖机制。方法:检测细胞周期和凋亡分析黄腐酚对PC3细胞增殖的影响;Western blot分析黄腐酚对Notch信号通路关键蛋白的作用。结果:黄腐酚可以抑制PC3细胞增殖,同时降低Notch信号通路活性。在黄腐酚对Notch信号通路的作用机制研究中发现,黄腐酚能够降低GSK-3β活性,引起Notch信号通路活性降低。结论:黄腐酚可能是通过抑制GSK-3β活性从而降低Notch信号通路活性,最终抑制PC3细胞的增殖。Objective：To investigate the mechanism of inhibition in proliferation of human prostate cancer PC3 cells by Xanthohumol.Methods：Examine the effect of Xanthohumol on PC3 proliferation using cell cycle and apoptosis analysis.Examine the effect of Xanthohumol on the key proteins of Notch signaling pathway by Western blot.Results：Xanthohumol inhibited the proliferation of PC3 and limited the activation of Notch signaling pathway.Xanthohumol can reduce GSK-3β activation,leading to the inactivation of Notch signaling pathways.Conclusion：Xanthohumol could inhibit human prostate cancer PC3 cell proliferation via reducing Notch signaling pathway activation by inhibition of GSK-3β activation.

关 键 词：黄腐酚 PC3 细胞增殖 NOTCH信号通路 GSK-3Β 

分 类 号：R737.25[医药卫生—肿瘤]