高能聚焦超声刀联合化疗治疗不能手术的结直肠癌肝转移的近期疗效  

Short-term efficacy of high intensity focused ultrasound combined with chemotherapy for colorectal cancer patients with liver metastases

作　　者：吴倩 张文涛 沈健美 

机构地区：[1]南京市红十字医院肿瘤科,江苏南京210000

出　　处：《现代肿瘤医学》2016年第17期2755-2758,共4页Journal of Modern Oncology

摘　　要：目的:探讨高能聚焦超声刀联合化疗治疗不能手术的结直肠癌肝转移的近期疗效及不良反应。方法:96例结直肠癌肝转移的患者,分为实验组和对照组。实验组48例,给予FOLFOX方案、FOLFIRI方案或单药卡培他滨口服方案,同时给予病灶局部高能聚焦超声刀,对照组的化疗方案与实验组相同。比较两组患者的疗效及不良反应。结果:实验组有效率为45.83%,而对照组治疗有效率为20.83%,差异有统计学意义(P=0.03),不良反应分为血液学和非血液学不良反应,两组患者的不良反应无统计学差异(P>0.05)。结论:高能聚焦超声刀联合化疗可以提高结直肠癌肝转移治疗的有效率,且不增加患者不良反应。Objective：To evaluate the efficacy and toxicity of chemotherapy combined with high intensity focused ultrasound in the patients with liver metastases of colorectal cancer.Methods：Ninety-six patients with liver metastases of colorectal cancer were enrolled in study.These 96 patients were assigned into two groups：48 patients in the study group treated with chemotherapy plus high intensity focused ultrasound,48 patients in the control group treated with chemotherapy alone.Based on NCCN guideline the chemotherapy was administrated with FOLFOX（ oxaliplatin plus 5-fluorouracil） or with FOLFIRI（ irinotecan plus 5-fluorouracil） or capecitabine.The efficacy and the toxicity were observed.Results：The response rate（ CR ＋ PR） in the study group was 45.83% and the response rate（ CR ＋PR） in the control group was 20.83%.There was significant difference（ P = 0.03）.Meanwhile,the hematologic toxicity and the non-hematologic toxicity were also observed.No statistically significant differences were found in the hematologic and non-hematologic toxicity（ P〉0.05）.Conclusion：The efficacy of chemotherapy combined with high intensity focused ultrasound was statistically higher than chemotherapy alone among the patients with liver metastases of colorectal cancer.The hematologic toxicity and non-hematologic toxicity was not different.

关 键 词：结直肠癌 肿瘤转移 高能聚焦超声刀 化疗 

分 类 号：R735.3[医药卫生—肿瘤]