人表皮生长因子受体-2及雌激素受体与乳腺癌的关系  

The relation of breast cancer with human epidermal growth factor receptor 2 and estrogen receptor

作　　者：郭奕阳[1] 张金艳[1] 

机构地区：[1]河北医科大学第四医院检验科,河北石家庄050011

出　　处：《现代肿瘤医学》2016年第17期2802-2805,共4页Journal of Modern Oncology

基　　金：河北省卫生厅科研基金项目(编号:ZL20140109)

摘　　要：乳腺癌与人表皮生长因子受体-2及雌激素受体关系密切,这两种受体也是乳腺癌的分类标准和治疗靶点。在大多数乳腺癌患者中,人表皮生长因子受体-2信号途径和雌激素受体信号途径参与了细胞的增生存活过程。而且在乳腺癌病例中,人表皮生长因子受体-2和雌激素受体呈现出一定程度的负相关。这说明这两种受体活化后有一些联系。本文简要综述了人表皮生长因子受体-2和雌激素受体的联系以及这种联系在乳腺癌治疗中的意义。Human epidermal growth factor receptor 2 and estrogen receptor were found in breast cancer.Breast cancer was classified by human epidermal growth factor receptor 2 and estrogen receptor.The estrogen receptor and the human epidermal growth factor receptor 2 signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancer.There was an inverse correlation between the human epidermal growth factor receptor 2 and the estrogen receptor in many breast cancer cases.There was a correlation between the human epidermal growth factor receptor 2 signaling pathways and the estrogen receptor signaling pathways.We reviewed the correlation and the clinical use of the correlation.

关 键 词：乳腺癌 人表皮生长因子受体-2 雌激素受体 

分 类 号：R737.9[医药卫生—肿瘤]