ING4基因的抗肿瘤作用研究进展  

Research progress in the mechanism of ING4 suppress cancer metastasis

作　　者：代魏魏 唐丽萍[1] 卢文[1] 

机构地区：[1]哈尔滨医科大学附属第三医院外科,黑龙江哈尔滨150040

出　　处：《现代肿瘤医学》2016年第17期2827-2830,共4页Journal of Modern Oncology

摘　　要：生长抑制因子4(ING4)是2003年发现并克隆出的抑癌基因ING家族新成员,是肿瘤抑制基因p53活动所必需的一个蛋白家族,能抑制肿瘤血管生成、增强p53基因的活性、抑制HIF的活性、抑制接触抑制的丢失、诱导细胞凋亡、增加肿瘤的放化疗敏感性、抑制肿瘤细胞侵袭转移。本文就ING4的基因结构、生物学功能及与恶性肿瘤的关系、作用机制及其临床意义作一综述。ING4（ inhibitor of growth 4） is a new member of the ING family which is 2003 discovered.It is necessary in the tumor suppressor gene p53 protein family activating.It may not only suppress tumor growth through angiogenesis repression but also enhanceme p53 activity.Furthermore,it may inhibit HIF activity,suppression of loss of contact inhibition,induce apoptosis enhancement,chemoradiosensitization of tumor cells,inhibition of tumor cell invasion and metastasis.In this review,we provide an overview of its biology function,the relationships with tumor metastasis,action mechanism and clinical significance.

关 键 词：ING4 抑癌机制 P53 肿瘤 

分 类 号：R730[医药卫生—肿瘤]