胃癌淋巴结分期的临床变革及分期方法的研究进展  

Research progress on clinical transformation and staging of lymph node in gastric cancer

作　　者：金俊蕊 邓靖宇[1] 梁寒[1] 

机构地区：[1]天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2016年第15期683-689,共7页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81572372);天津市科委应用基础与前沿技术研究计划项目(编号:15JCYBJC24800);天津市科委重点项目(编号:13ZCZCSY20300)资助~~

摘　　要：淋巴结转移被认为是影响胃癌患者预后十分重要的因素之一,准确合理的淋巴结分期对判断患者病程、评估预后及制定合理的治疗方案均有重要意义。最近国内外各研究中心发现,胃癌预后相关的淋巴结新分期方法如淋巴结转移率(metastastic lymph nodes ratio,r N)、阳性淋巴结对数比(log odds of positive lymph nodes,LODDS)、阴性淋巴结数(negative lymph node count,NLNC)及淋巴结微转移(lymph node micrometastasis,LNMM)等,也能较好的预测患者的预后。本文就胃癌淋巴结分期的发展历史、现状及胃癌预后相关的淋巴结新分期方法的研究进展进行综述。Lymph node metastasis is one of the important factors influencing the prognosis of gastric cancer patients. Accurate and reasonable lymph node staging is greatly significant in evaluating the course of the disease, in estimating the prognosis, and in making a reasonable treatment plan. Local and international research institutions recently found that new staging methods for lymph nodes associated with the prognosis of gastric cancer （e.g., metastastic lymph nodes ratio, log odds of positive lymph nodes, negative lymph node count, and lymph node micrometastasis） can also predict the prognosis of gastric cancer patients. In this paper, the development history, current status of lymph node staging of gastric cancer, and research progress on the new staging methods for lymph nodes as-sociated with the prognosis of gastric cancer are reviewed.

关 键 词：胃癌 淋巴结分期 淋巴结转移率 阳性淋巴结对数比 阴性淋巴结数 微转移 隐匿肿瘤细胞 

分 类 号：R735.2[医药卫生—肿瘤]