美沙拉嗪颗粒联合美常安胶囊对溃疡性结肠炎患者临床疗效及炎症反应的影响  

Effect of Mesalamine Combined with Medilac-S on Clinical Symptoms and Inflammatory Response in Patients with Ulcerative Colitis

作　　者：梁勇 颜丽萍 苏林 李弘 闫玉栋 

机构地区：[1]桂林市第二人民医院消化内科,广西桂林541000

出　　处：《现代生物医学进展》2016年第23期4520-4522,4567,共4页Progress in Modern Biomedicine

摘　　要：目的:研究美沙拉嗪颗粒联合美常安胶囊治疗溃疡性结肠炎的临床疗效及对炎症反应的影响。方法:选取本院自2015年1月至2016年1月收治的92例轻、中度溃疡性结肠炎患者,随机分为对照组和治疗组各46例。对照组单独行美沙拉嗪颗粒治疗,治疗组行美沙拉嗪颗粒联合美常安胶囊治疗,总疗程16周。对比观察两组患者治疗后对临床症状、临床症状积分、有效率以及炎症指标的改变。结果:治疗组患者的症状改善情况、总有效率均显著高于对照组(P<0.05),治疗组术前术后临床症状评分也明显优于对照组(P<0.05);两组患者治疗后红细胞沉降率(ESR)和C-反应蛋白(CRP)均明显降低,且治疗组降低更显著,差异有统计学意义(P<0.05)。结论:美沙拉嗪颗粒联合美常安胶囊可有效提高轻、中度溃疡性结肠炎治疗效果,减轻炎症反应,改善患者临床症状,临床效果显著,值得推广和应用。Objective： Toresearch the clinical symptoms and inflammatory response of mesalamine combined medilac-S for ulcerative colitis. Methods： 92 cases of mild, moderate ulcerative colitis who were admitted to our hospital from January 2015 to January 2016 divided into two groups randomly, control group and treatment group, 46 cases in each. The control group were only treated with mesalamine and the others were treated with mesalamine combined medilac-S, both of them used the medicine for 16 weeks. Then we compared the clinical symptoms, the clinical symptom score, the effective rate and the change of the index of inflammation between the two groups. Results： The symptomatic improvement total and effective rate in the treatment group were higher than the control group（P〈0.05）. The improvement of the clinical symptom score in the treatment group was better than the control group（P〈0.05）. Compared with the pre/post-treatment of ESR and CRP between the two groups, the treatment group was also better than the control group（P〈0.05）. The erythrocyte sedimentation rate（ESR）and C-reactive protein（CRP）were significantly decreased in the two groups after treatment, and the treatment group decreased more significantly, the difference was statistically significant（P〈0.05）. Conclusion： The mesalamine combined medilac-S can effectively improve the mild to moderate ulcerative colitis, reduce the inflammatory reaction, improve the clinical symptoms of patients. The clinical effect of this method is significant and it is worthy to promotion and application.

关 键 词：溃疡性结肠炎 美沙拉嗪 美常安 临床疗效 炎症反应 

分 类 号：R574.62[医药卫生—消化系统]