细胞因子对内皮祖细胞功能影响的研究进展  

Research Progress in the Effects of Cytokines on Endothelial Progenitor Cell Function

作　　者：秦廷江 杜明成[1] 夏世辉 王朝辉[1] 刘盈贝 安永[1] 

机构地区：[1]重庆医科大学附属儿童医院胸心外科儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室,重庆400014

出　　处：《现代生物医学进展》2016年第23期4582-4585,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(NSFC 81370432);重庆市自然科学基金项目(cstc2016jcyj A0827);国家临床重点专科建设项目(国卫办医函[2013]544);重庆市教委科学技术研究项目(KJ1500238)

摘　　要：内皮祖细胞(EPCs)是一种具有较强增殖能力的前体细胞,血管损伤或者缺血会刺激骨髓EPCs动员,迁移、归巢于相应的靶位,然后分化为内皮细胞(ECs),从而参与血管修复和血管新生。因此,EPCs的成功发现为缺血性和血管损伤性疾病的治疗提供了新策略。但是EPCs存在动员率低、靶向性较差和功能不全等问题。大量研究显示细胞因子对EPCs的动员、归巢、增殖和分化等均起着重要的调节作用,同时,通过调控细胞因子能改善EPCs的功能活性,因此选择合适的细胞因子来提高EPCs功能变得非常重要。现总结了近年来细胞因子对EPCs功能影响的研究进展,并提出有待解决的问题和作一定的展望。Endothelial progenitor cells（EPCs） are a kind of precursor cell with high proliferative potential. Vascular injury or ischemia can stimulate EPCs mobilization from the bone marrow, migration and homing to sites of vascular injury or ischemia, and then differentiate into mature ECs, to promote the formation of new vessels and repair vessels. So the successful discover of EPCs have provided a new method to treat the ischemic and vascular injury disease. But the EPCs have some problems, such as low mobilization, poor homing, dysfunction and so on. Numerous studies have shown that cytokines play an important role on the function of EPCs. Meanwhile, the functional activity of EPCs can be improved by regulating cytokines. Therefore, it’s very important to improve the function of EPCs by selecting the appropriate cytokines. This review summarizes the recent research progress about the effects of cytokines on endothelial progenitor cell function and puts forward some problems to be solved and perspectives in the future.

关 键 词：细胞因子 内皮祖细胞 研究进展 

分 类 号：R363.2[医药卫生—病理学] R54[医药卫生—基础医学]