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作 者:乔晓慧[1] 邢晋放[1,2] 张佳杰[1] 高峰[2] 杜联芳[2]
机构地区:[1]南京医科大学附属上海一院临床医学院超声医学科,上海200080 [2]上海交通大学附属第一人民医院超声医学科,上海200080
出 处:《现代生物医学进展》2016年第24期4640-4642,4667,共4页Progress in Modern Biomedicine
基 金:上海申康医院发展中心临床科技创新项目(SHDC22015011);上海交通大学医学院科技基金项目(14XJ10075);上海交通大学附属第一人民医院院级科研项目(0601N16004)
摘 要:目的:利用实时剪切波弹性成像(shear wave elastography,SWE)定量分析不同睾酮水平阴茎组织硬度之间的差异。方法:睾酮水平不同SD大鼠两组,低睾酮水平组(1月龄,睾酮水平1.00-1.50 ng/mL,n=10)和高睾酮水平组(13月龄,睾酮水平2.00-2.50ng/mL,n=10)。采用放射免疫法测定各组大鼠血清睾酮水平。选用法国Super Sonic Imagine公司生产的Aixplorer超声诊断仪,启动SWE模式对阴茎进行SWE成像并测量其剪切波硬度(shear wave stiffness,SWS)。分析比较两组大鼠血清睾酮水平之间的差异及SWS之间的差异。结果:所有大鼠血清睾酮水平及阴茎组织SWS的测量均成功完成。低睾酮水平组大鼠血清睾酮水平为(1.30±0.16)ng/mL,高睾酮水平组为(2.29±0.14)ng/mL,两组大鼠血清睾酮水平存在显著差异(P〈0.01);低睾酮水平组大鼠阴茎组织SWS为(9.86±0.72)kPa,高睾酮水平组为(7.80±1.43)kPa,两组大鼠阴茎组织SWS存在显著差异(P〈0.01)。结论:SWE可以检测出睾酮水平不同导致的阴茎组织硬度的差异,提示SWE可作为一项评价阴茎组织硬度的无创新技术。Objective: To quantitatively analyze the differences of penis stiffness with different levels of testosterone using shear wave elastography (SWE). Methods: Two groups of SD rats with different levels of testosterone: the low testosterone group (1 month, testosterone 1.00-1.50 ng/mL, n=10) and the high testosterone group (13 month, testosterone 2.00-2.50 ng/mL, n=10). The radioimmunoassay was used to measure the level of testosterone and the ultrasound device Aixplorer (SuperSonic Imagine, Aix-en-Provence, France) was used for the SWE imaging and SWS measurement of penis. The differences of the level of testosterone between the two groups and SWS between the two groups were analyzed. Results: The level of testosterone and SWS of penis were all successfully measured. The level of testosterone of the two groups was respectively (1.30± 0.16) ng/mL and (2.29± 0.14) ng/mL, there were significant differences of the level of testosterone between the two groups (P〈0.01). The penis SWS of the two groups was respectively (9.86± 0.72) kPa and (7.80± 1.43) kPa, there were significant differences of penis SWS between the two groups (P〈0.01). Conclusion: The differences of penis stifthess with different levels of testosterone can be detected using SWE. Therefore, SWE maybe serve as a potential noninvasive method of evaluating the penis stiffness.
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