腹腔镜胃癌根治术联合局部植入氟尿嘧啶缓释剂治疗中晚期胃癌的疗效  

Efficacy of intraperitoneally implanting 5-fluorouracil sustained-release agent during laparoscopic radical gastrectomy for advanced gastric cancer

作　　者：杜军[1] 费伯健[1] 蒋晖[1] 金留根[1] 高其忠[1] 

机构地区：[1]无锡市第四人民医院胃肠(腔镜)外科,江苏省214062

出　　处：《江苏医药》2016年第15期1681-1683,共3页Jiangsu Medical Journal

摘　　要：目的观察腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗中晚期胃癌的疗效。方法中晚期胃癌患者125例分为两组:试验组58例,采用腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗;对照组67例,实施腹腔镜胃癌根治术治疗。比较两组疗效和相关的不良反应发生情况。结果两组在手术时间和手术、化疗相关并发症等方面无统计学差异(P>0.05)。随访8~25个月:试验组2年无病生存时间长于对照组[(25.0±3.8)个月vs.(17.0±1.5)个月](P<0.05),2年复发率低于对照组(39.7%vs.52.2%)(P<0.05),2年生存率高于对照组(72.4%vs.55.2%)(P<0.05)。结论腹腔镜胃癌根治术联合植入氟尿嘧啶缓释剂治疗中晚期胃癌可行,是一种有效且并发症少的腹腔化疗方法。Objective To observe the efficacy of intraperitoneally implanting 5-fluorouracil sustained-release agent during laparoscopic radical gastrectomy for advanced gastric cancer. Methods One hundred and twenty five cases with advanced gastric cancer were divided into two groups of A （treated with laparoscopic D2 radical gastrectomy and intraperitoneally implanting 5-fluorouraeil sustained-release agent, 58 cases） and B（treated with laparoscopic D2 radical gastrectomy, 67 cases）. The efficacy and relevant adverse effects were compared between two groups. Results There were no significant differences between two groups in operative time, complication and chemotherapy-related adverse effects （P〉0. 05）. The patients were followed up for 8-25 months, which showed that the disease-free survival timeE（25.0±3. 8） months vs. （17.0±1.5） months3 was longer, 2-year relapse rate（39.7% vs. 52.2%） was lower, and 2-year survival rate（72. 4% vs. 55.2%） was significantly higher in group A than those in group B（P^0. 05）. Conclusion As an intraperitoneal chemotherapy, intraperitoneally implanting of 5-fluorouracil sustained-release agent during laparoseopie D2 radical gastrectomy is feasible and effective in the patients with advance gastric cancer with mild side effects.

关 键 词：胃癌 氟尿嘧啶缓释剂 腹腔镜胃癌根治术 

分 类 号：R735[医药卫生—肿瘤]