SIAH1蛋白表达与乳腺癌新辅助化疗疗效和临床特征的相关性研究  

Study of the relationship between SIAH1 protein expression and clinical features and efficacy of neoadjuvant chemotherapy in breast cancer

作　　者：钱立勇[1] 温媛媛[1] 徐勇飞[1] 孔琼琼 

机构地区：[1]浙江省舟山医院病理诊断中心

出　　处：《中国临床药理学与治疗学》2016年第7期792-795,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省舟山市科技局基金资助项目2015C31034

摘　　要：目的:探讨SIAH1蛋白表达与乳腺癌新辅助化疗疗效和临床特征的关系。方法:采用免疫组织化学S-P法检测123例乳腺癌患者的活检石蜡包埋组织中SIAH1蛋白的表达情况,其中56例患者接受术前新辅助化疗,分析SIAH1蛋白的表达情况与新辅助化疗疗效和临床特征的关系。结果:SIAH1蛋白的表达情况与新辅助化疗疗效以及部分临床特征相关,SIAH1蛋白高表达者的新辅助化疗有效率高于低表达者(P<0.05),SIAH1蛋白表达与组织学分级和临床分期相关(P<0.05)。结论:乳腺癌患者的SIAH1蛋白表达状况可能成为预测新辅助化疗的敏感性指标,同时可能成为乳腺癌的预后指标。AIM： To investigate the relationship between the expression of SIAH1 protein, the effica- cy of neoadjuvant chemotherapy and the clinical characteristics in breast cancer. METHODS： Im- muno histochemical S-P method was applied to de- tect the expression of SIAH1 proteins in biopsied and paraffin embedded tissue of 123 breast cancer pa- tients, 56 of which received neoadjuvant chemother- apy to analyze the relationship between the expres- sion of SIAH1, the efficacy of neoadjuvant chemo- therapy and the clinical characteristics. RESULTS： The expression of SIAH1 protein was associated with the efficacy of neoadjuvant chemotherapy and the clinical characteristics. The efficacy of neoadjuvant chemotherapy in SIAH1 protein higher expression was significantly higher than lower expression （P 〈 0.05）, and the expression of SIAH1 protein was found related with organizational grades and clinical characteristics （ P 〈 0.05 ）. CONCLUSION ： The expression of SIAH1 protein may be a predictive marker for neoadjuvant chemotherapy as well as a prognostic marker for breast cancer.

关 键 词：乳腺肿瘤 SIAH1 新辅助化疗 疗效 临床特征 

分 类 号：R737.9[医药卫生—肿瘤]