钙化性纤维性肿瘤7例临床病理分析  

Calcifying fibrous tumor: a clinicopathological study of 7 cases

作　　者：杨旭丹[1] 王晓卿[1] 王雷[1] 傅静[1] 刘裔莎[1] 徐钢[1] 

机构地区：[1]四川省医学科学院四川省人民医院病理科,成都610072

出　　处：《诊断病理学杂志》2016年第8期574-577,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨钙化性纤维性肿瘤（CFT）的临床特征、组织来源、形态学和免疫表型特点及其鉴别诊断。方法对7例钙化性纤维性肿瘤进行常规HE染色及免疫组化染色观察，并结合临床资料对其进行临床病理特征分析。结果本组患者年龄9-71岁，发病部位分别为附睾旁、回肠系膜、腰部皮下、升结肠系膜、肾脏旁各1例及胃体2例。镜下示肿瘤在结节状胶原化的纤维组织内伴有特征性砂砾体或营养不良性钙化形成，可见淋巴细胞、浆细胞浸润。免疫组化示瘤细胞vimentin（＋），CD117、Dog-1、CD34、SMA、CK、desmin、β-catenin、ALK-1和S-100蛋白均（-），Ki-67指数〈1％。随访7例患者均生存良好。结论CFT是一种少见的良性纤维性肿瘤，其诊断需要结合组织形态及免疫组化，注意与其他良性及中间性问叶肿瘤相鉴别。Objective To study the clinicopathological characteristics, etiology, immunophenotype and differential diagnosis of calcifying fibrous tumor by presenting 7 cases and a review of literature. Methods Seven cases of calcifying fibrous tmnor were studied by routine histological examination, immunohistochemical staining, together with analyzing the clinicopathological features and reviewing the literature. Results Patients aged 9 to 71 years, tumors were located in the paraepididymal, mesoileum, subcutaneous tissue of lumbus, ascending mesocolon, next to the kidney and two cases of gastric body. Histological features showed nodules of abundant collagenous fiber with the psammomatous body or dystrophic calcification and scattered lymphocyte and plasma cell infiltration. Immunohistochemieally, all the cases expressed vimentin,CD117, DOG1, CD34, SMA, CK, desmin, β-catenin and ALK-1, S-100 protein were negative, and the index of Ki-67 was less than 1%. Follow-up of all the cases showed good survival. Conclusion CFT is a rare benign fibrous tumor, which requires a combination of histological and immunohistochemical features to differential diagnosis from other benign and malignant benign and intemnediate mesenchymal tumors.

关 键 词：钙化性纤维性肿瘤 免疫组化 鉴别诊断 

分 类 号：R730.262[医药卫生—肿瘤]