LEEP联合膦甲酸钠治疗高级别CIN伴高危型HPV感染的临床研究  

Clinical research of LEEP combined with foscarnet sodium in treatment of high-grade cervical intraepithelial neoplasia with high risk HPV infection

作　　者：王静[1] 周燕[1] 夏利花[1] 余晓 

机构地区：[1]浙江中医药大学附属衢州中心医院妇科,浙江衢州324000 [2]浙江省衢州市妇幼保健医院妇科,浙江衢州324000

出　　处：《中国现代医生》2016年第21期21-24,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2016ZB138);浙江省衢州市科技计划项目(2013080)

摘　　要：目的观察LEEP联合膦甲酸钠治疗高级别CIN伴高危型HPV感染的临床疗效,探索治疗新方法。方法选取2013年1月～2014年12月在我院诊断为高级别CIN（CINⅡ/Ⅲ）伴高危HPV感染患者107例,随机分为对照组和观察组,对照组LEEP术后无特殊处理,观察组LEEP术后静脉滴注膦甲酸钠,比较两组治疗后HPV的转阴率、TCT的变化、CIN的残留率与复发率。结果治疗后3、6、12个月,观察组的HPV转阴率分别为89.2%、95.0%、93.0%,高于对照组的70.5%、74.5%、72.5%,差异有统计学意义（治疗后3个月P〈0.05,治疗后6、12个月P〈0.01）;观察组TCT的正常比例分别为89.3%、89.3%、92.8%,大于对照组的68.6%、74.5%、78.4%,差异有统计学意义（治疗后3个月P〈0.01,治疗后6、12个月P〈0.05）;观察组CIN的残留率与复发率分别为5.4%、1.8%、3.6%;低于对照组的19.6%、13.7%、17.6%,差异有统计学意义（P〈0.05）。结论 LEEP联合膦甲酸钠治疗高级别CIN伴高危型HPV感染的效果优于单纯LEEP治疗,弥补了单纯手术的不足,为临床提供了治疗的新方法。Objective To observe the clinical effect of LEEP combined with foscarnet sodium in treatment of high-grade cervical intraepithelial neoplasia with high risk HPV infection and explore new treatment method. Methods From January 2013 to December 2014, One hundred and seven patients diagnosed with high-grade cervical intraepithelial neoplasia with high risk HPV infection were randomly divided into control group and observation group. The control group was treated with the LEEP alone,while the observation group was given the intravenous administration of foscarnet sodium on the basis of the treatment in the control group. The negative rate of high risk HPV, the changes of TCT and the residual and recurrence rate of CIN were compared in the two groups. Results The observation group＇s negative rate of high risk HPV was 89.2%, 95.0%, 93.0% after 3, 6 and 12 months, higher than that of the control group, whose negative rate was 68.6%, 74.5%, 78.4%, and the difference was statistically significant（P〈0.01 after 3 month, P〈0.05 after 6, 12 month）. The observation group＇s normal rate of TCT was 89.3%, 89.3%, 92.8%, higher than that of the control group, whose normal rate was 68.6%,74.5%,78.4%, and the difference was statistically significant（P〈0.01 after 3month, P〈0.05 after 6,12 month）. The observation group ＇s residual and recurrence rate of CIN was 5.4%, 1.8%, 3.6%,lower than that of the control group,whose residual and recurrence rate was 19.6%, 13.7%, 17.6%, and the difference was statistically significant（P〈0.05）. Conclusion LEEP combined with foscarnet sodium in treatment of high-grade cervical intraepithelial neoplasia with high risk HPV infection is more effective than simply LEEP, make up for the deficiency and provides a new method for clinical treatment.

关 键 词：高危型HPV 高级别CIN LEEP 膦甲酸钠 

分 类 号：R737.33[医药卫生—肿瘤]