两种剂量的曲安奈德玻璃体腔注射联合激光治疗黄斑水肿的疗效比较  

Comparison between 2mg and 4mg intravitreal triamcinolone acetonide combined with laser photocoaguiation for diabetic macular edema

作　　者：周慧兰[1] 翁伟君 戴丹[1] 王丁丁[2] 

机构地区：[1]中国广东省惠州市第三人民医院眼科,516000 [2]中国广东省惠州市中心人民医院眼科,516000

出　　处：《国际眼科杂志》2016年第9期1692-1694,共3页International Eye Science

摘　　要：目的:不同剂量的曲安奈德玻璃体腔注射联合激光光凝术治疗黄斑水肿的疗效比较。方法:前瞻性研究,2014-07/2015-10就诊于我院的黄斑水肿患者,随机纳入2mg组和4mg组54例54眼,进行曲安奈德玻璃体腔注射,术后2wk^1mo进行视网膜激光光凝治疗,术后1、3、6mo随访患者视力、黄斑厚度、有无并发症等情况。结果:2mg组和4mg组患眼曲安奈德玻璃体腔注射联合激光光凝术后均可使患者视力提高,黄斑厚度变薄,与各自治疗前比较差异有显著统计学意义(P<0.01);两组治疗前后不同时间点视力提高和黄斑厚度变薄程度相互比较,差异无统计学意义(P>0.05);两组并发症发生率比较差异无统计学意义(P>0.05)。结论:2mg曲安奈德玻璃体腔注射联合激光光凝术治疗黄斑水肿,疗效与4mg剂量相当,临床可选择2mg剂量代替4mg。AIM：To compare the efficiency of different dose of intravitreous injection combined with laser photocoagulation in patients with macular edema（ME）.METHODS：Prospective research.Eighty-four of 54 patients with macular edema were randomized into 2mg group and 4mg group.Eyes were subjected to laser photocoagulation from 2 to 4wk after intravitreal injection of triamcinolone acetonide.At 1mo,3mo,6mo after treatment follow up,the corrected visual acuity,central macular thickness（CMT） and development of any side effects was measured between the 2mg group and 4mg group.RESULTS：The vision was obviously improved and the CMT values were reduced after injection compared with before injection in both two groups（P〈0.01） and no evident differences were seen in vision at various time points between two groups（P〈0.05）.There was no difference in the happening to the side effects between two groups.CONCLUSION：This study suggests that both 2mg and4 mg intravitreal triamcinolone acetonide combined with laser photocoagulation appears to have an effect on visual improvement,decreasing retinal thickness.Group of 2mg represents a relatively safe treatment of macular edema.It is an attempt to use 2mg triamcinolone acetonide to replace 4mg triamcinolone acetonide in macular edema.

关 键 词：黄斑水肿 治疗 激光凝固术 曲安奈德 

分 类 号：R779.63[医药卫生—眼科]