BANCR对甲状腺乳头状癌TSHR表达调控的研究进展  

Research Progress of the regulation of BANCR on the expression of TSHR in thyroid papillary carcinoma

作　　者：郝少龙[1] 刘新承 马纪红[2] 姜立新[1] 郑海涛[1] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院甲状腺外科,264000 [2]青岛大学附属医院内分泌科,266003

出　　处：《中华普外科手术学杂志（电子版）》2016年第4期358-360,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

摘　　要：目的本文通过综述相关文献并分析甲状腺乳头状癌(PTC)发生发展过程中TSH/TSHR/c AMP和Ras/Raf/MEK/ERK(MAPK通路)两条信号通路,探讨了BRAF激活的长链非编码RNA(BANCR)对PTC组织中促甲状腺激素受体(TSHR)表达调节表达调控的意义。BANCR表达上调可能会使PTC组织中TSHR的表达降低,从而促进了PTC的发生发展,并可能影响患者预后。因此,明确BANCR对PTC组织TSHR表达调控的作用机制,有助于进一步明确PTC的发生机制,并可能会为PTC的临床诊断和治疗提供新的靶标。We reviewed literatures and discussed the role of BANCR on the regulation of the expression of thyroid stimulating hormone receptor （ TSHR ） in thyroid papillary carcinoma by signaling pathways of TSH/TSHR/cAMP and Ras/Raf/MEK/ERK （ MAPK pathway ） in the development of papillary thyroid carcinoma （ PTC） .BANCR up-regulation would reduce TSHR expression in PTC , which might affect the prognosis of patients with PTC .As a consequence , it is helpful to further clarify the mechanism of PTC that explore the mechanism of regulation of the expression of TSHR in PTC by BANCR , which could provide a new target for the clinical diagnosis and treatment of PTC .

关 键 词：甲状腺肿瘤 癌 乳头状 受体 甲状腺激素 MAP激酶信号系统 

分 类 号：R736.1[医药卫生—肿瘤]