血清尿酸与非酒精性脂肪性肝病的相关性研究  

Association between serum uric acid and nonalcoholic fatty liver disease

作　　者：范能光[1] 张丽娟[2] 夏振华[2] 彭亮[3] 沈伟勤 徐浣白[1] 王育璠[1] 彭永德[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢科,200080 [2]上海交通大学附属第一人民医院松江分院内分泌代谢科 [3]上海交通大学附属第一人民医院松江分院检验科 [4]上海交通大学附属第一人民医院松江分院体检中心

出　　处：《中国糖尿病杂志》2016年第8期678-682,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金青年项目(81400785)

摘　　要：目的 研究普通人群血清尿酸（SUA）水平与非酒精性脂肪性肝病（NAFLD）的关系。方法 收集27615名体检者的临床和生化资料,并通过腹部B超诊断NAFLD。将研究对象分为非NAFLD（Non-NAFLD）组和NAFLD组,再根据不同性别的SUA四分位数将研究对象分为4组（Q1~Q4）,比较各组临床和生化特征。结果 本研究中,NAFLD及高尿酸血症（HUA）的患病率分别为27.1%和19.6%。随SUA水vs29.3%vs 46.2%,趋势P〈0.001）;多元Logistic回归分析发现,校正性别、年龄、BMI、BP、血脂等因素后,Q2~Q4组的NAFLD患病风险较Q1组分别增加24%、62%和137%（P〈0平的升高,BMI、SBP、DBP、TG、TC、LDL-C、Scr、ALT和AST均升高,HDL-C降低（趋势P〈0.001）;从Q1组至Q4组,NAFLD的患病率逐渐递增（13.5%vs 19.9%.001）。结论 在普通人群中,SUA与NAFLD密切相关,可能是NAFLD发生的独立危险因素。Objective To investigate the association between serum uric acid （SUA） and nonalcoholic fatty liver disease （NAFLD） in general population. Methods The clinical and laboratory data of 27,615 subjects who underwent medical examination were collected. NAFLD was diagnosed by B ultrasound. All subjects were divided into Non-NAFLD group （n= 20119） and NAFLD group （n= 7496）, and divided into four groups （QI-Q4） by quartile of SUA based on gender again. Clinical and laboratory data were compared among groups. Results The prevalence of NAFLD and high SUA was 27. 1% and 19.6 %0, respectively. BMI, SBP, DBP, TG, TC, LDL-C, Scr, ALT and AST significantly increased with the increase of SUA levels, while HDL C level deceased （P for trend 〈0. 001）. The prevalences of NAFLD in participants with high SUA from lowest quartile （Q1） to highest quartile （Q4） were 13.50%, 19.9%, 29.3%and 46.2%,respectively （P for trend 〈0. 001）. Logistic regression analysis showed that the risks of NAFLD in Q2, Q3 and Q4 groups increased by 24 %, 62% and 137 %, respectively, as compared with Q1 group （P〈 0. 001） after adjustment of gender, age, BMI, BP, blood lipid. Conclusion SUA is slgnflicantiy aand independently assocmted with NAFLD in general population.

关 键 词：血清尿酸 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]