影像增强剂对脑瘤螺旋断层放疗剂量计算的影响  

Effects of image intensifier on dose calculation of helical tomotherapy for brain tumor

作　　者：徐艳红[1] 张晋建[1] 黎静[1] 李志强[1] 文婷[1] 钟毓[1] 王彦[1] 贾峻嵩[1] 陈静[1] 

机构地区：[1]广州军区广州总医院螺旋断层放疗中心,广东广州510010

出　　处：《中国医学物理学杂志》2016年第8期757-760,共4页Chinese Journal of Medical Physics

基　　金：广东省社会发展领域科技计划(2013B021800051)

摘　　要：目的:研究影像增强剂对脑瘤螺旋断层放疗(HT)计划剂量计算的影响,探讨使用定位CT增强图像替代平扫图像用于靶区勾画和剂量计算的临床可行性。方法:收集30例脑瘤病例,所有病例均在增强图像上勾画靶区和危及器官轮廓,再把靶区和危及器官轮廓复制到平扫图像上。在HT计划系统中分别以增强图像和平扫图像设计两组放疗计划,比较两组靶区和危及器官的CT值、剂量分布和治疗时间。结果:两组图像的CT值在瘤区域(PGTV)处具有统计学差异(P<0.05),其他组织CT值比较无统计学差异;计划靶区和危及器官的剂量学、治疗时间等参数的差异比较均无统计学差异(P>0.05)。结论:影像增强剂对脑瘤HT计划剂量计算影响极小,脑瘤放疗中可以使用定位CT增强图像替代定位CT平扫图像用于靶区勾画和螺旋断层放疗计划剂量计算。Objective To investigate the effect of image intensifier on the dose calculation of helical tomotherapy（HT） plan for brain tumors, and to evaluate the clinical feasibility of localization CT enhanced image replacing plain CT scan image for target delineation and dose calculation. Methods Thirty cases of brain tumors were collected. The contours of planning target volume（PTV） and organs at risk（OARs） of each case were delineated in the enhanced image, and the contours of PTV and OARs were copied to plain scan image. Two plans based on the enhanced image and plain scan image were designed in the planning system of HT. The CT value, dose distribution and treatment time of PTV and OARs were compared between the two groups. Results Statistical differences were found in the CT value of planning gross target volume（P〈0.05）, and no statistical differences were found in the CT values of other tissue. No statistical differences were found in the dosimetry of PTV and OARs, and treatment time（P〉0.05）. Conclusion The image intensifier has little effect on the dose calculation of HT for brain tumor. In the radiotherapy for brain tumor, the localization CT enhanced image can be used to replace the plain CT scan image for target delineation and dose calculation

关 键 词：脑肿瘤 影像增强剂 增强图像 平扫图像 螺旋断层放疗 剂量计算 

分 类 号：R730.55[医药卫生—肿瘤]