湖北地区炎症因子基因多态性与动脉粥样硬化性脑梗死的关系  

The observation of the relationship between polymorphisms of inflammatory factors and susceptibility of atherosclerotic cerebral infarctionin a Han population in Hubei province

作　　者：艾志兵[1] 杜玲[2] 李龙倜[1] 罗国君[2] 

机构地区：[1]湖北省十堰市太和医院神经内科,湖北医药学院附属医院,湖北十堰442000 [2]上海交通大学附属第六人民医院金山分院神经科,上海201500

出　　处：《中风与神经疾病杂志》2016年第8期693-695,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨相关炎症因子基因多态性与中国湖北地区汉族人群动脉粥样硬化性脑梗死（atherosclerotic cerebral infarction,ACI） 的关系.方法在湖北汉族人群中筛选 260 例脑梗死患者为脑梗死组;200 例健康体检者为对照组,采用聚合酶链式反应-限制性片段长度多态性（ polymerase chain reaction-restriction fragment length polymarphism ,PCR-RFIP）方法测定炎症因子基因多态性.结果脑梗死组与对照组比较,BRAP基因外显子90A/G分布存在统计学差异（χ2 =11.2,P〈0.05）,IL-15基因的C/A人基因型分布不存在组间统计学差异（χ2 =3.220,P〉0.05）,Logistic 回归分析提示,BRAP基因外显子90GG 等位基因携带者发生ACI的风险是CC等位基因的1.8倍（OR=1.476,95% CI 1.142 ~2. 268）,且该关联独立于性别、年龄、吸烟、高血压等风险因素.没有证据表明IL-15基因13687 C/A 位点单核苷酸多态性与动脉粥样硬化性脑梗死易感性相关.结论BRAP 90A/ G 外显子基因多态性与动脉粥样硬化性脑梗死发病有关,可能是中国湖北地区汉族人群动脉粥样硬化性脑梗死发病的遗传易感基因.Objective To investigate the relationship between polymorphisms of inflammatory factors and susceptibilityof atherosclerotic cerebral infarction （ ACI） in a Han population in Hubei province. Methods 260 patients were assignedto the ACI group,the other 200 normal patients were assigned to the control group. Then the distributions of alleleand genotype frequencies of inflammatory factors were detected by polymerase chain reactionk-restriction fragment lengthpolymorphism. Results We found significant difference in genotype of 90 A / G polymorphism of BRAP gene （χ2 =11.2 ,P〈 0.05） and no difference in genotype of 13687C/A polymorphism of IL-15 gene （χ2 =3. 220,P 〉0. 05） between ACI patientsand controls; Compared with BRAP gene exon 90 CC carrier,90 GG genotypes had a significantly increased ACI riskby Logistic regression analysis（ OR = 1.476,95% CI 1. 142 ~2. 268 ） , this association was still significant after adjustmentfor the sex, age, smoke, hypertension. No evidence of association was found for IL-15 gene 13687C/A polymorphisms.Conclusion The 90 A/G polymorphism in the BRAP gene may be associated with increased risk one of the predisposinggenes of ACI and among Hubei province Chinese Han population.

关 键 词：动脉粥样硬化性脑梗死 脑梗死基因多态性 白细胞介素-15 乳腺癌易感基因相关蛋白基因 

分 类 号：R743.1[医药卫生—神经病学与精神病学]