XRCC1基因Arg399Gln多态性与中国人群神经胶质瘤易感性Meta分析  

Association between XRCC1 Arg399Gln polymorphism and glioma risk in Chinese population: a meta- analysis

作　　者：王美钧[1] 王雪玢 邱石黎[2] 张献伟[2] 柴红燕[2] 李莲[1] 涂建成[2] 

机构地区：[1]十堰市人民医院检验部,湖北十堰442000 [2]武汉大学中南医院基因诊断中心,湖北武汉430071

出　　处：《现代肿瘤医学》2016年第18期2875-2878,共4页Journal of Modern Oncology

基　　金：国家重点基础研究发展计划973计划(编号:2012CB720600)

摘　　要：目的：探讨XRCC1基因Arg399Gln（G/A）多态性与中国人群神经胶质瘤易感性的关系。方法：计算机检索Pubmed、EMBASE、中国知网、万方期刊、维普等中英文数据库,检索2014年10月之前公开发表的相关文献,对符合标准的文献采用NOS量表评价文献质量,应用Rev Man5.1软件进行Meta分析。结果：共纳入9篇与XRCC1基因Arg399Gln多态性与神经胶质瘤易感性相关的病例对照研究,包括7 131例患者,其中病例组3 428例,对照组3 703例,NOS评分≥6分为高质量文献,仅2项研究质量评分〈6。Meta分析结果显示携带A等位基因可增加中国人群神经胶质瘤的患病风险（OR=1.20,95%CI：1.04~1.38,P=0.01）。结论：中国人群中XRCC1基因Arg399Gln（G/A）多态性与神经胶质瘤的易感性存在相关性。Objective： We investigated the relationship between the polymorphism of XRCC1 Arg399 Gln and glioma in Chinese population. Methods： The electronic databases Pubmed,EMBASE,China National Knowledge Infrastructure,Wanfang and VIP databases Data were searched. The selected literatures which published before Oct 2014 were evaluated based on Newcastle- Ottawa Scale（ NOS） score. Meta- analysis was performed by Rev Man 5. 1 software. Results： Nine studies were included in this meta- analysis with a total of 7 131 subjects,including 3 428 cases group and 3 703 control group. Seven included studies were with NOS score≥6,and only 2 included studies were with NOS score 6. Meta- analysis showed that individuals with 399 A XRCC1 allele were at higher risk of increased the glioma risk（ OR = 1. 20,95% CI = 1. 04 ~ 1. 38,P = 0. 01）. Conclusion： XRCC1 Arg399 Gln polymorphisms may play a role in the susceptibility of glioma in Chinese population.

关 键 词：XRCC1基因 神经胶质瘤 多态性 META分析 

分 类 号：R730.264[医药卫生—肿瘤]