浆液性卵巢肿瘤组织中DCR3、Survivin、PDCD5的表达  

Expressions of DCR3,Survivin and PDCD5 in serous ovarian tumor

作　　者：马莉[1] 康石清[1] 苗莉[1] 靳耀锋[1] 康安静[1] 

机构地区：[1]西安交通大学第二附属医院病理科,陕西西安710004

出　　处：《现代肿瘤医学》2016年第18期2943-2946,共4页Journal of Modern Oncology

基　　金：陕西省科学技术研究发展计划项目(编号:2012SF2-03-04)

摘　　要：目的:探讨DCR3、Survivin、PDCD5凋亡相关基因在浆液性卵巢肿瘤组织中的表达。方法:采用免疫组化及Real-time PCR两种方法观察浆液性囊腺瘤16例、交界性浆液性囊腺瘤25例、浆液性囊腺癌48例组织中DCR3、Survivin、PDCD5的蛋白及mRNA表达。结果:DCR3、Survivin、PDCD5在卵巢浆液性囊腺瘤组织的细胞浆或核未见明显的棕黄色颗粒沉着,而在交界性浆液性囊腺瘤组织的细胞浆或核中可见弱的棕黄色颗粒沉着,浆液性囊腺癌可见强的棕黄色颗粒沉着。与卵巢浆液性囊腺瘤组相比,交界性浆液性囊腺瘤、浆液性囊腺癌中DCR3、Survivin、PDCD5 mRNA表达水平显著增高(P<0.05)。结论:DCR3、Survivin、PDCD5凋亡相关基因在浆液性卵巢肿瘤中的蛋白及mRNA表达变化呈一致升高的趋势,其机制可能与调控凋亡有关,进而参与了卵巢肿瘤的发生发展过程,并可为卵巢肿瘤的防治提供一些新策略。Objective： To explore expressions of DCR3,Survivin,PDCD5 in serous ovarian tumor. Methods： Expressions of DCR3,Survivin,PDCD5 in 16 serous cystadenoma,25 borderline serous cystadenoma,48 serous cystadenocarcinoma tissues were determined with SP immunohistochemical method and Real- time PCR. Results： Protein and mRNA expressions of DCR3,Survivin,PDCD5 in serous cystadenocarcinoma were significantly stronger than that in serous cystadenoma and borderline serous cystadenoma（ P〈0. 05）. Conclusion： Protein and mRNA expressions of apoptosis related gene DCR3,Survivin,PDCD5 in serous ovarian tumor are elevated. This mechanism might be related to the regulation of apoptosis,and then participate in the development of ovarian tumor,which providing some new strategies for the prevention and treatment of ovarian tumor.

关 键 词：浆液性卵巢肿瘤 DCR3 SURVIVIN PDCD5 凋亡 

分 类 号：R737.31[医药卫生—肿瘤]