肠道菌群在自发性细菌性腹膜炎发生发展中的作用  

Role of intestinal flora in the development and progression of spontaneous bacterial peritonitis

作　　者：栾雨婷 蔡文君[1] 徐莹[1] 刘平[1] 慕永平[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203

出　　处：《临床肝胆病杂志》2016年第8期1622-1625,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81173223;81573948)

摘　　要：自发性细菌性腹膜炎(SBP)是肝硬化的主要并发症之一。近年来,随着高通量测序技术及肠道宏基因组学研究等生物技术的发展,肠道菌群在肝脏疾病中的作用越来越受到关注,细菌易位特别是来自肠道革兰阴性肠杆菌的易位参与了SBP的发生发展。简述了SBP发生发展的各种相关因素及肠道菌群在SBP中发挥的重要作用。生物技术的提高使肠道菌群在疾病中的作用日渐清晰,恢复肠道菌群平衡有望成为防治SBP的新思路。Spontaneous bacterial peritonitis（ SBP） is a major complication of liver cirrhosis. In recent years,with the development of biotechnology,such as high- throughput sequencing and intestinal metagenomics,the role of intestinal flora in liver diseases has been taken more and more seriously. Bacterial translocation,especially the translocation of Gram- negative enteric bacilli,is involved in the development and progression of SBP. This article briefly describes the factors related to the development and progression of SBP and the important role of intestinal flora in SBP. The improvement in biotechnology clarifies the role of intestinal flora in diseases,and restoration of balanced intestinal flora may become a new method for the prevention and treatment of SBP.

关 键 词：腹膜炎 肠杆菌科 细菌移位 综述 

分 类 号：R572.2[医药卫生—消化系统]