肝癌发生、发展过程中部分基因表达异常对其诊断及治疗的意义  

Abnormal expression of some genes in the occurrence and development of hepatocellular carcinoma and their significance for the diagnosis and treatment of hepatocellular carcinoma

作　　者：龚由之 江应安[1] 

机构地区：[1]武汉大学人民医院感染科,湖北武汉430060

出　　处：《胃肠病学和肝病学杂志》2016年第8期848-851,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肝癌(hepatocellular carcinoma,HCC)是最常见肿瘤之一,同时也是肿瘤致死第三大病因,全球每年死亡人数约60万。即使经过有效的局部用药或外科治疗,HCC仍易复发与转移,再加上导致HCC的病因众多,所以HCC的治疗相当困难。然而,HCC发生、发展过程中出现的基因表达的变化,为我们诊断及治疗HCC提供了新的思路。Hepatocellular carcinoma（ HCC） is one of the most common tumors and is the third leading cause of cancer death,accounting for approximately 600 000 deaths annually. With so many pathgenesis leading to HCC,controlling HCC is difficult,as recurrence or metastasis is quite common in patients,even after the application of successful topical therapies or curative hepatectomy. However,abnormal expression of some genes in the occurrence and development of HCC paves new way to the diagnosis and treatment of HCC.

关 键 词：肝癌 致癌基因 抑癌基因 表观遗传学改变 

分 类 号：R735.7[医药卫生—肿瘤]