降钙素原及炎症指标在急性胰腺炎早期的临床价值研究  

The clinical value of procalcitonin and inflammatory cytokines in acute pancreatitis

作　　者：李敏利[1] 吕莉慧[2] 张晓华[1] 许小兵[1] 金鑫鑫[1] 吴晓尉[1] 王彬[1] 

机构地区：[1]南京军区南京总医院消化内科,江苏南京210002 [2]南京军区南京总医院干部保健科,江苏南京210002

出　　处：《胃肠病学和肝病学杂志》2016年第8期896-898,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：南京军区南京总医院科研基金(2012064)

摘　　要：目的探讨降钙素原(procalcitonin,PCT)和各种炎症指标在急性胰腺炎(acute pancreatitis,AP)早期的表达及对治疗和预后的评估价值。方法收集南京军区南京总医院2015年1月-2015年11月收治的AP患者49例,根据严重程度不同将患者分为3组:轻症急性胰腺炎组(mild acute pancreatitis,MAP)18例、中重症急性胰腺炎组(moderately severe acute pancreatitis,MSAP)20例、重症急性胰腺炎组(severe acute pancreatitis,SAP)11例;分别检测患者入院后第1天、第3天、第7天血清PCT及炎症相关指标C反应蛋白(CRP)、白细胞计数(WBC)、白介素-6(IL-6)变化。结果入院第1天WBC明显升高,但各组同时间点比较,差异无统计学意义(P>0.05);第3天时PCT和WBC在MAP组和MSAP组指标最高,与其他各时间点比较,差异有统计学意义(P<0.05);SAP组第7天达高峰,与其他各时间点比较,差异有统计学意义(P<0.05);入院后随住院时间延长,CRP和IL-6均明显升高,各组间各时间点比较,差异有统计学意义(P<0.05)。结论血清PCT及相关炎症指标在AP早期诊治过程中有重要价值,对临床指导治疗和判断预后有重要意义。Objective To explore the effects of procalcitonin（ PCT） and early inflammatory cytokines and assessment of the values as well as in the treatment and prognosis of acute pancreatitis（ AP）. Methods Forty-nine patients with AP were collected from Jan. 2015 to Nov. 2015,and then divided into 3 groups： mild acute pancreatitis group（ MAP） with 18 patients,moderately severe acute pancreatitis group（ MSAP） with 20 patients and severe acute pancreatitis group（ SAP） with 11 patients. Serum PCT,c-reactive protein（ CRP）,white blood cells（ WBC） and interleukin6（ IL-6） were detected on the days of 1,3 and 7. Results WBC was increased obviously at the 1st day,but there was no statistically significant difference in each group at the same time（ P 〉0. 05）. PCT and WBC were the highest levels in MAP and MSAP groups at the 3rd day,and there were significant differences compared with other time points（ P 〈0. 05）; while PCT and WBC were the highest levels in SAP group at the 7th day,compared with other time points,the difference was statistically significant（ P 〈0. 05）. With the length of hospital stay,CRP and IL-6 were increased obviously,there were significant differences among three groups at each time point（ P 〈0. 05）. Conclusion Serum PCT and related inflammatory cytokines have important values in the process of early diagnosis and treatment of AP.

关 键 词：降钙素原 炎症指标 急性胰腺炎 感染 

分 类 号：R576[医药卫生—消化系统]