鼻咽癌MR表观扩散系数预测近期放疗敏感性的相关分析  

Relationship Between ADC Value and Treatment Sensitivity in Primary Lesion of Nasopharyngeal Carcinoma

作　　者：李伟[1,2] 汤日杰[2] 卢斌贵[2] 张海南[2] 桂思[2] 李颖慧[2] 

机构地区：[1]广州医科大学附属肿瘤医院核医学科 [2]广州医科大学附属肿瘤医院放射科,广东广州510095

出　　处：《中国CT和MRI杂志》2016年第9期5-8,共4页Chinese Journal of CT and MRI

基　　金：广州市医药卫生科技项目(20141A011093)

摘　　要：目的探讨利用ADC值预测鼻咽癌治疗敏感性的价值。方法 142例鼻咽癌在治疗前行MR扩散加权成像检查,获得原发灶的ADC值。按照治疗后鼻咽癌原发灶影像变化进行治疗敏感性分组,敏感组104例、抗拒组38例。比较敏感性分组与ADC值、T分期的关系。通过ROC曲线分析ADC值预测敏感性的价值。结果 T1-T4的ADC值分别为(0.818±0.111)×10^(-3)mm^2/s、(0.756±0.169)×10^(-3)mm^2/s、(0.684±0.119)×10^(-3)m m^2/s、(0.667±0.093)×10^(-3)mm^2/s,整体上存在显著性差异(F=6.595,P=0.000)。敏感组的ADC值(0.747±0.141)×10^(-3)mm^2/s大于抗拒组(0.658±0.129)×10^(-3)mm^2/s,t=3.421、P=0.001。在敏感组内,T1-T4的ADC值整体上不存在显著性差异。结论 ADC值和肿瘤乏氧、T分期密切相关,可成为预测鼻咽癌治疗效果的有效手段。鼻咽癌治疗敏感性有随着ADC值的升高而升高的趋势。Objecte To investigate the value of ADC value in predicting the treatment sensitivity of nasopharyngeal carcinoma （NPC）. Met：hods 142 cases of NPC were performed MR diffusion weighted imaging, and the ADC values of primary foci were obtained. According to the treatment results, these cases were divided to sensitive group （104 cases） and resistance group （38 cases）. To analyze the relationship among groups, ADC values and T staging, estimate the value of ADC value in predicting the treatment sensitivity through the Az value of P, OC curve. Results The ADC vales of T1 （0.818±0.111） × 10-3mm2/s, T2 （0.756±0.169） ×10-3mm2/s, T3 （0.684±0.119） ×10- 3mm2/s and T4 （0.667 ± 0.093） × 10-3mm2/s were significantly different on the whole （F=6.595, P=0.000）. The ADC value of the sensitive group （747 ± 0.141）10-3mm2/s was greater than that in the resistance group （0.658 ± 0.129） × 10-3mm2/s, （t=3.421, P=0.001）. In sensitive group, TI （0.822±0.114） × 10-3mm2/s, T2 （0.773±0. 161）×10-3mm2/s, T3 （0.697 ± 0.114） × 10-3mm2/s and T4 （0.747 ± 0.091） × 10-3mm2/s were significantly different on the whole （F=3.945, P=0.010）. In resistance group, T1 and T4 were not significantly different on the whole. Conclusion ADC value is closely related to treatment sensitivity and T staging, which can be an effective method for predicting the treatment effect of nasopharyngeal carcinoma. The therapeutic sensitivity of NPC increased with the increase of ADC values.

关 键 词：鼻咽癌 ADC值 扩散加权成像 敏感性 治疗效果 

分 类 号：R739.6[医药卫生—肿瘤]