2-羟基-1-萘醛缩对氨基水杨酸希夫碱铬配合物的合成及体外抗肿瘤活性研究  

Synthesis of chromium complex of 2-hydroxy-1-naphthaldehyde-4-aminosalicylic acid Schiff base and its in vitro anti-tumor activity

作　　者：王水英[1] 刁海鹏[2] 傅力明[2] 

机构地区：[1]山西省肿瘤医院普外科,太原030013 [2]山西医科大学基础医学院医学化学教研室

出　　处：《中国药物与临床》2016年第8期1096-1098,共3页Chinese Remedies & Clinics

基　　金：山西省自然科学基金(2013011060-3)

摘　　要：目的合成2-羟基-1-萘醛缩对氨基水杨酸希夫碱铬配合物药物并研究其体外抗肿瘤作用。方法采用常规加热回流法合成化合物,利用紫外吸收、红外光谱、元素分析等方法对其进行表征。采用四甲基偶氮唑盐(MTT)法考察合成的药物对人肝癌细胞HepG-2、人结肠腺癌细胞LS174T、人胃腺癌细胞SGC-7901增殖的抑制作用。结果铬配合物的组成为[C_(36)H_(26)N_2O_8Cr]·2H_2O;对HepG-2、LS174T和SGC-7901细胞都有不同程度的抑制作用,并呈现良好的剂量-效应关系,对HepG-2、LS174T的活性明显大于SGC-7901;对HepG-2、LS174T和SGC-7901癌细胞的半数抑制浓度分别为0.008 0μmol/L、0.012 5μmol/L和0.022 5μmol/L。结论 2-羟基-1-萘醛缩对氨基水杨酸希夫碱铬配合物能抑制Hep G-2、LS174T和SGC-7901细胞的生长,在体外有良好的抗肿瘤活性。Objective To investigate the synthesis of chromium complex of 2-hydroxy-l-naphthaldehyde-4-aminosalicylic acid Schiff base and its in vitro anti-tumor activity. Methods The chromium complex was obtained by conventional heating reflux. It was characterized by UV absorption, infrared spectroscopy （IR） and elemental analysis. MTT assay was used to determine the inhibition of the synthetic drug onproliferation of human liver cancer cells HepG-2, human colon cancer cells LS174T, and human gastric cancer cells SGC-7901. Results The molecular formula of the chromium complex was [C36H26N2O8Cr]· 2H2O. The chromium complex showed different degrees of inhibi- tion on HepG-2, LS174T and SGC-7901 ceils, with good dose-response relationship. Its anti-tumor activity on HepG-2 and LS174T cells was better than that on SGC-7901 cells.The half maximal inhibitory concentration （IC50） on the 3 types of cancer cells HepG-2, LSI74T and SGC-7901 were 0.008 0 μmol/L, 0.012 5 μmol/L and 0.022 5 μmol/L, respectively. Conclusion Chromium complex of 2-hydroxy-l-naphthaldehyde-4-aminosalicylicacid Schiff base can inhibit the growth of HepG-2, LSI74T and SGC-7901 ceils, which shows good in vitro anti-tumor activity.

关 键 词：希夫碱类 铬化合物 抗肿瘤活性 

分 类 号：R914.5[医药卫生—药物化学] R96[医药卫生—药学]