和厚朴酚环糊精纳米海绵的制备及表征研究  

Preparation of Honokiol Loaded β-Cyclodextrin Nanosponges and Its Properties

作　　者：邓凤[1] 徐才兵[2] 贾运涛[3] 邓萍[1] 张良珂[1] 

机构地区：[1]重庆医科大学药学院,重庆市生物化学与分子药理学重点实验室,重庆400016 [2]重庆三峡中心医院,重庆404000 [3]重庆医科大学附属儿童医院药剂科,重庆400010

出　　处：《中国药学杂志》2016年第16期1390-1393,共4页Chinese Pharmaceutical Journal

基　　金：重庆市自然科学基金资助项目(cstc2012jj A10021);高等学校博士学科点专项科研基金(20125503120003);重庆医科大学大学生科学研究与创新实验资助项目(201432,201244,201217);重庆市教育委员会科学技术研究项目(KJ120307)

摘　　要：目的制备和厚朴酚环糊精纳米海绵,考察环糊精纳米海绵对和厚朴酚的增溶作用,并对其理化性质进行初步考察。方法采用β-环糊精与碳酸二苯酯合成环糊精纳米海绵,并用红外光谱法(FT-IR)和热分析法(DSC)进行验证。结果和厚朴酚环糊精纳米海绵在DSC中无和厚朴酚的特征吸收峰,FT-IR中1 780 cm^(-1)左右出现新的羰基峰。体外释放实验中和厚朴酚环糊精纳米海绵5 h的累积释放为88.57%,而和厚朴酚混悬液仅为46.55%。纳米海绵使和厚朴酚在水中的溶解度增加了8.87倍。结论成功制备了和厚朴酚环糊精纳米海绵,显著提高了和厚朴酚的溶解度。OBJECTIVE To prepare the honokiol-loaded β-cyclodextrin-based nanosponges （HK-NSP） and investigate their physicochemical properties. METHODS β-Cyclodextrin-based nanosponges （NSP） was obtained by reacting β-cyclodextrin with diphenyl carbonate and the effect of NSP on houokiol solubilization was investigated. Moreover, NSP and HK-NSP were validated by FT- IR and DSC. RESULTS The FT-IR of HK-NSP showed the presence of the carbonate bond as evidenced by a peak at 1 780 cm^-1, and the DSC of HK-NSP did not showed the melting peak corresponding to drug fusion. The percentage of HK released from NSP after 5 h in phosphate buffer solution was 88.57% , and that from HK suspension was only 46.55%. Moreover, NSP showed 8.87 times solubilization efficiency for HK. CONCLUSION HK-NSP are successfully prepared, and the solubility of HK is improved by the NSP obviously.

关 键 词：和厚朴酚 Β-环糊精 纳米海绵 溶解度 

分 类 号：R284[医药卫生—中药学]